Prognostic factors of postoperative morbidity in surgery for resectable pancreatic cancer. Regional institute of neoplastic diseases 'Dr. Luis Pinillos Ganoza' IREN Norte. 2007-2022.

IF 1.2 Q4 ONCOLOGY

ecancermedicalscience Pub Date : 2024-09-05 eCollection Date: 2024-01-01 DOI:10.3332/ecancer.2024.1754

Aldaír Guzmán-Aponte, Juan Alberto Díaz-Plasencia, Edgar Fermín Yan-Quiroz, José Richard Tenazoa-Villalobos

{"title":"Prognostic factors of postoperative morbidity in surgery for resectable pancreatic cancer. Regional institute of neoplastic diseases 'Dr. Luis Pinillos Ganoza' IREN Norte. 2007-2022.","authors":"Aldaír Guzmán-Aponte, Juan Alberto Díaz-Plasencia, Edgar Fermín Yan-Quiroz, José Richard Tenazoa-Villalobos","doi":"10.3332/ecancer.2024.1754","DOIUrl":null,"url":null,"abstract":"Objective: To determine the prognostic factors associated with postoperative morbidity for resectable pancreatic cancer at the Instituto Regional de Enfermedades Neoplásicas del Norte 'Dr. Luis Pinillos Ganoza' - IREN Norte. 2007-2022.Materials and methods: A study was conducted with a case-based (22 patients) and control (14 patients) design nested in a cohort that included 36 patients who underwent proximal duodenopancreatectomy (Whipple) or distal pancreatectomy for pancreatic cancer.Results: In the present study, it was found that the total number of living patients represents 86.1% of the total (36 patients). Of the total population, patients who presented only 1 complication were 13.6% and more than 1 complication were 86.4%. It was also found that the most frequent complication in the general population was gastric emptying syndrome, which was present in 50% of all patients. In the bivariate analysis, a highly significant association was observed between the low prognostic nutritional index (p < 0.001, OD = 20.400, CI = 95%: (3.377-123.245)), the type of pancreatic resection (p < 0.001, OR = 52.500, CI = 95%: (5.174-532.669)) and postoperative morbidity. In contrast, no significant association was found between age ≥65 (p = 0.062), diabetes mellitus (p < 0.908), Wirsung diameter (p < 0.432), hospital stay (p < 0.075) and postoperative morbidity. In the multivariate analysis, serum total bilirubin level ≥20 μmol/L (p = 0.778), use of preoperative biliary drainage (p = 0.176), type of pancreatojejunal anastomosis (p = 0.533) and pancreaticogastric anastomosis (p = 0.504) were not statistically significantly associated with postoperative morbidity.Conclusion: The type of pancreatic resection and the nutritional prognostic index <40.5 are prognostic factors of postoperative morbidity in postoperative patients for resectable pancreatic cancer.","PeriodicalId":11460,"journal":{"name":"ecancermedicalscience","volume":"18 ","pages":"1754"},"PeriodicalIF":1.2000,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489101/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ecancermedicalscience","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3332/ecancer.2024.1754","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Objective: To determine the prognostic factors associated with postoperative morbidity for resectable pancreatic cancer at the Instituto Regional de Enfermedades Neoplásicas del Norte 'Dr. Luis Pinillos Ganoza' - IREN Norte. 2007-2022.

Materials and methods: A study was conducted with a case-based (22 patients) and control (14 patients) design nested in a cohort that included 36 patients who underwent proximal duodenopancreatectomy (Whipple) or distal pancreatectomy for pancreatic cancer.

Results: In the present study, it was found that the total number of living patients represents 86.1% of the total (36 patients). Of the total population, patients who presented only 1 complication were 13.6% and more than 1 complication were 86.4%. It was also found that the most frequent complication in the general population was gastric emptying syndrome, which was present in 50% of all patients. In the bivariate analysis, a highly significant association was observed between the low prognostic nutritional index (p < 0.001, OD = 20.400, CI = 95%: (3.377-123.245)), the type of pancreatic resection (p < 0.001, OR = 52.500, CI = 95%: (5.174-532.669)) and postoperative morbidity. In contrast, no significant association was found between age ≥65 (p = 0.062), diabetes mellitus (p < 0.908), Wirsung diameter (p < 0.432), hospital stay (p < 0.075) and postoperative morbidity. In the multivariate analysis, serum total bilirubin level ≥20 μmol/L (p = 0.778), use of preoperative biliary drainage (p = 0.176), type of pancreatojejunal anastomosis (p = 0.533) and pancreaticogastric anastomosis (p = 0.504) were not statistically significantly associated with postoperative morbidity.

Conclusion: The type of pancreatic resection and the nutritional prognostic index <40.5 are prognostic factors of postoperative morbidity in postoperative patients for resectable pancreatic cancer.

查看原文本刊更多论文

可切除胰腺癌手术中术后发病率的预后因素。路易斯-皮尼略斯-加诺萨博士 "地区肿瘤性疾病研究所（IREN Norte）。2007-2022.

目的确定与 "路易斯-皮尼略斯-加诺萨博士"--IREN Norte 区域肿瘤研究所可切除胰腺癌术后发病率相关的预后因素。材料与方法研究以病例（22 例患者）和对照（14 例患者）为基础，在包括 36 例因胰腺癌接受近端十二指肠切除术（Whipple）或远端胰腺切除术的患者的队列中进行嵌套设计：本研究发现，在世患者占总人数（36 人）的 86.1%。在所有患者中，仅出现一种并发症的患者占 13.6%，出现一种以上并发症的患者占 86.4%。研究还发现，一般人群中最常见的并发症是胃排空综合征，占所有患者的 50%。在双变量分析中，低预后营养指数（P < 0.001，OD = 20.400，CI = 95%：(3.377-123.245）、胰腺切除类型（P < 0.001，OR = 52.500，CI = 95%：(5.174-532.669)) 和术后发病率。相比之下，年龄≥65（p = 0.062）、糖尿病（p < 0.908）、Wirsung 直径（p < 0.432）、住院时间（p < 0.075）与术后发病率之间没有明显关联。在多变量分析中，血清总胆红素水平≥20 μmol/L（p = 0.778）、术前使用胆道引流（p = 0.176）、胰空肠吻合类型（p = 0.533）和胰胃吻合（p = 0.504）与术后发病率无显著统计学相关性：胰腺切除类型和营养预后指数

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊