EoE Recurrence on PPI Maintenance Therapy: You Do Not Know if You Do Not Look!

IF 2.5 4区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Digestive Diseases and Sciences Pub Date : 2024-11-01 Epub Date: 2024-10-15 DOI:10.1007/s10620-024-08676-3

Ryan Alexander, Blake Kassmeyer, Ryan Lennon, Jeffrey Alexander, Diana Snyder, Karthik Ravi

引用次数: 0

Abstract

Background and aims: Data regarding histologic recurrence of EoE on PPI maintenance therapy are lacking.

Methods: Retrospective review of 101 patients with histologic PPI-responsive EoE.

Results: 52/101 (51%) patients underwent follow-up EGD with biopsies. Of the 52 patients, 29 (56%) maintained histologic remission and 23 (44%) had histologic recurrence. 21 (40%) patients maintained BID PPI, 20 (39%) tapered to QD, and 11 (21%) had discontinued PPI. Of the 21 patients on BID PPI, 7 (33%) had histologic recurrence, of which 6 (86%) were asymptomatic.

Conclusions: Patients on PPI therapy for EoE benefit from serial clinical, endoscopic, and histologic surveillance.

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服用 PPI 维持疗法后 EoE 复发：不看不知道，一看吓一跳！

背景和目的缺乏有关PPI维持治疗后组织学复发的数据：方法：对101例PPI反应性组织学EoE患者进行回顾性研究：结果：52/101（51%）例患者接受了带有活检的后续胃肠道造影检查。在 52 名患者中，29 人（56%）保持组织学缓解，23 人（44%）组织学复发。21名患者（40%）继续服用双剂量 PPI，20 名患者（39%）减量至四剂量，11 名患者（21%）停用了 PPI。在21名服用双剂量PPI的患者中，7名（33%）出现组织学复发，其中6名（86%）无症状：结论：接受PPI治疗的EoE患者可从连续的临床、内镜和组织学监测中获益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Digestive Diseases and Sciences 医学-胃肠肝病学

CiteScore

6.40

自引率

3.20%

发文量

420

审稿时长

1 months

期刊介绍： Digestive Diseases and Sciences publishes high-quality, peer-reviewed, original papers addressing aspects of basic/translational and clinical research in gastroenterology, hepatology, and related fields. This well-illustrated journal features comprehensive coverage of basic pathophysiology, new technological advances, and clinical breakthroughs; insights from prominent academicians and practitioners concerning new scientific developments and practical medical issues; and discussions focusing on the latest changes in local and worldwide social, economic, and governmental policies that affect the delivery of care within the disciplines of gastroenterology and hepatology.