Negative 18 F-FDG and Positive 68 Ga-FAPI-04 Findings in a Patient With Acute Exacerbation of Chronic Cholecystitis.

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-04-01 Epub Date: 2024-10-14 DOI:10.1097/RLU.0000000000005504

Na Qi, Jie Ding, Haiyan Wang, Jun Zhao

引用次数: 0

Abstract

Abstract: Acute cholecystitis typically exhibits intense FDG uptake of the gallbladder wall. Radiolabeled fibroblast activation protein inhibitor (FAPI) is considered as a potential alternative agent for tumor-specific imaging. We report 18 F-FDG and 68 Ga-FAPI-04 PET/MR findings in a 44-year-old woman with acute exacerbation of chronic cholecystitis. The lesions show negative 18 F-FDG uptake but intense 68 Ga-FAPI-04 uptake in PET/MR. This case highlights the imperative for nuclear medicine clinicians to exercise vigilance when evaluating gallbladder lesions exhibiting intense 68 Ga-FAPI-04 but negative 18 F-FDG uptake.

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一名慢性胆囊炎急性加重患者的 18F-FDG 阴性和 68Ga-FAPI-04 阳性结果。

摘要：急性胆囊炎通常会在胆囊壁上表现出强烈的 FDG 摄取。放射性标记的成纤维细胞活化蛋白抑制剂（FAPI）被认为是肿瘤特异性成像的潜在替代药物。我们报告了一名患有慢性胆囊炎急性加重的 44 岁女性的 18F-FDG 和 68Ga-FAPI-04 PET/MR 结果。病变显示 18F-FDG 摄取阴性，但在 PET/MR 中 68Ga-FAPI-04 摄取强烈。本病例强调了核医学临床医生在评估表现出强 68Ga-FAPI-04 摄取但 18F-FDG 摄取阴性的胆囊病变时必须保持警惕。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.