Mitochondrial Maintenance in Skeletal Muscle.

IF 6.9 2区 生物学 Q1 CELL BIOLOGY
Laura M de Smalen, Christoph Handschin
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引用次数: 0

Abstract

Skeletal muscle is one of the tissues with the highest range of variability in metabolic rate, which, to a large extent, is critically dependent on tightly controlled and fine-tuned mitochondrial activity. Besides energy production, other mitochondrial processes, including calcium buffering, generation of heat, redox and reactive oxygen species homeostasis, intermediate metabolism, substrate biosynthesis, and anaplerosis, are essential for proper muscle contractility and performance. It is thus not surprising that adequate mitochondrial function is ensured by a plethora of mechanisms, aimed at balancing mitochondrial biogenesis, proteostasis, dynamics, and degradation. The fine-tuning of such maintenance mechanisms ranges from proper folding or degradation of individual proteins to the elimination of whole organelles, and in extremis, apoptosis of cells. In this review, the present knowledge on these processes in the context of skeletal muscle biology is summarized. Moreover, existing gaps in knowledge are highlighted, alluding to potential future studies and therapeutic implications.

骨骼肌中的线粒体维护
骨骼肌是新陈代谢率变化范围最大的组织之一,而新陈代谢率在很大程度上取决于线粒体活动的严格控制和微调。除了产生能量外,线粒体的其他过程,包括钙缓冲、产生热量、氧化还原和活性氧平衡、中间代谢、底物生物合成和无氧代谢,对肌肉的正常收缩能力和表现都至关重要。因此,旨在平衡线粒体生物生成、蛋白稳态、动态和降解的大量机制确保了线粒体功能的充分发挥也就不足为奇了。这些维持机制的微调范围从单个蛋白质的适当折叠或降解到整个细胞器的消除,以及极端情况下的细胞凋亡。在这篇综述中,我们总结了目前在骨骼肌生物学背景下有关这些过程的知识。此外,还强调了现有的知识空白,暗示了未来潜在的研究和治疗意义。
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来源期刊
CiteScore
15.00
自引率
1.40%
发文量
56
审稿时长
3-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Biology offers a comprehensive platform in the molecular life sciences, featuring reviews that span molecular, cell, and developmental biology, genetics, neuroscience, immunology, cancer biology, and molecular pathology. This online publication provides in-depth insights into various topics, making it a valuable resource for those engaged in diverse aspects of biological research.
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