Mid- and long-term renal outcomes after metabolic surgery in a multi-center, multi-ethnic Asian cohort with T2DM.

IF 3.9 2区 医学 Q1 UROLOGY & NEPHROLOGY
Clinical Kidney Journal Pub Date : 2024-10-09 eCollection Date: 2024-10-01 DOI:10.1093/ckj/sfae260
Yueh-Chu Sio, Ching-Yi Chen, Yu-Min Huang, Wei-Jei Lee, Kyoung Yul Hur, Kazunori Kasama, Anton Kui Sing Cheng, Ming-Hsien Lee, Kin-Hung Wong Simon, Tien-Chou Soong, Kuo-Ting Lee, Davide Lomanto, Muffazal Lakdawala, Yen-Hao Su, Weu Wang, Hsi-Hsien Chen
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引用次数: 0

Abstract

Background: Metabolic surgery is recognized for its effectiveness in weight loss and improving outcomes for individuals with type 2 diabetes mellitus (T2DM). However, its impact on renal function, especially in multi-ethnic Asian populations, remains underexplored. This study investigates mid- and long-term renal outcomes following metabolic surgery in Asian patients with T2DM.

Methods: This retrospective cohort study utilized data from the Asian Diabetes Surgery Study (ADSS), involving T2DM patients aged 20-79 who underwent metabolic surgery from 2008 to 2015. The primary outcome was the change in estimated glomerular filtration rate (eGFR) at 1, 3, and 5 years post-surgery, with adjustments for confounders. Secondary outcomes included changes in chronic kidney disease (CKD) stages and the relationship between weight loss and eGFR changes. Data were analyzed using univariate and multivariable regression analyses, along with the McNemar test.

Results: The study included 1513 patients with a mean age of 42.7 years. The results revealed that a significant improvement in eGFR was observed at 1-year post-surgery (112.4 ± 32.0 ml/min/1.73 m², < .001), with a shift toward less severe CKD stages. However, this improvement was not sustained at 3 and 5 years. No significant correlation was found between weight loss and eGFR changes at 1-year follow-up.

Conclusion: Metabolic surgery significantly improves renal function at 1 year postoperatively in Asian individuals with T2DM, highlighting its potential benefits beyond glycemic control and weight loss. The long-term effects on renal function require further investigation.

多中心、多种族亚洲 T2DM 患者队列中代谢手术后的中长期肾脏预后。
背景:代谢手术在减轻体重和改善 2 型糖尿病(T2DM)患者治疗效果方面的有效性已得到公认。然而,代谢手术对肾功能的影响,尤其是对多种族亚裔人群的影响,仍未得到充分探讨。本研究调查了T2DM亚裔患者接受代谢手术后的中长期肾功能结果:这项回顾性队列研究利用了亚洲糖尿病手术研究(ADSS)的数据,涉及 2008 年至 2015 年期间接受代谢手术的 20-79 岁 T2DM 患者。主要结果是术后1年、3年和5年估计肾小球滤过率(eGFR)的变化,并对混杂因素进行了调整。次要结果包括慢性肾脏病(CKD)分期的变化以及体重减轻与 eGFR 变化之间的关系。数据采用单变量和多变量回归分析以及 McNemar 检验进行分析:研究共纳入 1513 名患者,平均年龄为 42.7 岁。结果显示,术后 1 年的 eGFR 有明显改善(112.4 ± 32.0 ml/min/1.73 m²,P 结论:代谢手术能明显改善肾功能:代谢手术能明显改善患有 T2DM 的亚洲人术后 1 年的肾功能,凸显了其在控制血糖和减轻体重之外的潜在益处。对肾功能的长期影响还需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Kidney Journal
Clinical Kidney Journal Medicine-Transplantation
CiteScore
6.70
自引率
10.90%
发文量
242
审稿时长
8 weeks
期刊介绍: About the Journal Clinical Kidney Journal: Clinical and Translational Nephrology (ckj), an official journal of the ERA-EDTA (European Renal Association-European Dialysis and Transplant Association), is a fully open access, online only journal publishing bimonthly. The journal is an essential educational and training resource integrating clinical, translational and educational research into clinical practice. ckj aims to contribute to a translational research culture among nephrologists and kidney pathologists that helps close the gap between basic researchers and practicing clinicians and promote sorely needed innovation in the Nephrology field. All research articles in this journal have undergone peer review.
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