Viruses and Mitochondrial Dysfunction in Neurodegeneration and Cognition: An Evolutionary Perspective.

IF 3.6 4区医学 Q3 CELL BIOLOGY

Cellular and Molecular Neurobiology Pub Date : 2024-10-17 DOI:10.1007/s10571-024-01503-3

George B Stefano, Simon Weissenberger, Radek Ptacek, Martin Anders, Jiri Raboch, Pascal Büttiker

引用次数: 0

Abstract

Mitochondria, the cellular powerhouses with bacterial evolutionary origins, play a pivotal role in maintaining neuronal function and cognitive health. Several viruses have developed sophisticated mechanisms to target and disrupt mitochondrial function which contribute to cognitive decline and neurodegeneration. The interplay between viruses and mitochondria might be traced to their co-evolutionary history with bacteria and may reflect ancient interactions that have shaped modern mitochondrial biology.

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神经退行性变和认知中的病毒和线粒体功能障碍：进化的视角》。

线粒体是源自细菌进化的细胞动力室，在维持神经元功能和认知健康方面发挥着关键作用。一些病毒已经开发出针对和破坏线粒体功能的复杂机制，从而导致认知能力下降和神经退行性病变。病毒与线粒体之间的相互作用可追溯到它们与细菌共同进化的历史，并可能反映出塑造了现代线粒体生物学的古老相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular and Molecular Neurobiology 生物-神经科学

CiteScore

7.70

自引率

0.00%

发文量

137

审稿时长

4-8 weeks

期刊介绍： Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.