Emerging roles of noncoding RNAs in idiopathic pulmonary fibrosis.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2024-10-21 DOI:10.1038/s41420-024-02170-5

Haitao Wang, Kai Sun, Hao Peng, Yi Wang, Lei Zhang

引用次数: 0

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic lung disease with limited treatment options and efficacy. Evidence suggests that IPF arises from genetic, environmental, and aging-related factors. The pathogenic mechanisms of IPF primarily involve dysregulated repeated microinjuries to epithelial cells, abnormal fibroblast/myofibroblast activation, and extracellular matrix (ECM) deposition, but thus far, the exact etiology remains unclear. Noncoding RNAs (ncRNAs) play regulatory roles in various biological processes and have been implicated in the pathophysiology of multiple fibrotic diseases, including IPF. This review summarizes the roles of ncRNAs in the pathogenesis of IPF and their potential as diagnostic and therapeutic targets.

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非编码 RNA 在特发性肺纤维化中的新作用。

特发性肺纤维化（IPF）是一种慢性、进行性、纤维化肺部疾病，治疗方法和疗效有限。有证据表明，IPF 是由遗传、环境和衰老相关因素引起的。IPF 的致病机制主要包括上皮细胞反复微损伤失调、成纤维细胞/肌成纤维细胞活化异常以及细胞外基质（ECM）沉积，但迄今为止，确切的病因仍不清楚。非编码 RNA（ncRNA）在各种生物过程中发挥调控作用，并与包括 IPF 在内的多种纤维化疾病的病理生理学有关。本综述总结了 ncRNA 在 IPF 发病机制中的作用及其作为诊断和治疗靶点的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.