Functional diversity and regulation of IL-9-producing T cells in cancer immunotherapy

IF 9.1 1区医学 Q1 ONCOLOGY

Cancer letters Pub Date : 2024-10-18 DOI:10.1016/j.canlet.2024.217306

Muhammad Kalim , Rui Jing , Wei Guo, Hui Xing, Yong Lu

引用次数: 0

Abstract

IL-9-producing T cells (T9) regulate immunological responses that affect various cellular biological processes, though their precise function remains fully understood. Previous studies have linked T9 cells to conditions such as allergic disorders, parasitic infection clearance, and various types of cancers. While the functional heterogeneity of IL-9 and T9 cells in cancer development has been documented, these cells present promising therapeutic opportunities for treating solid tumors. This review highlights the roles of IL-9 and T9 cells in cancer progression and treatment responses, focusing on potential discrepancies in IL-9/IL-9R signaling between murine tumors and cancer patients. Additionally, we discuss the regulation of tumor-specific Th9/Tc9 cell differentiation, the therapeutic potential of these cells, and current strategies to enhance their anti-tumor activities.

查看原文本刊更多论文

癌症免疫疗法中产生 IL-9 的 T 细胞的功能多样性和调节。

产生 IL-9 的 T 细胞（T9）可调节影响各种细胞生物过程的免疫反应，但它们的确切功能仍有待全面了解。以前的研究已将 T9 细胞与过敏性疾病、寄生虫感染清除和各种癌症等病症联系起来。虽然 IL-9 和 T9 细胞在癌症发展中的功能异质性已被记录在案，但这些细胞为治疗实体瘤提供了大有可为的治疗机会。本综述强调了IL-9和T9细胞在癌症进展和治疗反应中的作用，重点研究了小鼠肿瘤和癌症患者之间IL-9/IL-9R信号传导的潜在差异。此外，我们还讨论了肿瘤特异性 Th9/Tc9 细胞分化的调控、这些细胞的治疗潜力以及增强其抗肿瘤活性的当前策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer letters 医学-肿瘤学

CiteScore

17.70

自引率

2.10%

发文量

427

审稿时长

15 days

期刊介绍： Cancer Letters is a reputable international journal that serves as a platform for significant and original contributions in cancer research. The journal welcomes both full-length articles and Mini Reviews in the wide-ranging field of basic and translational oncology. Furthermore, it frequently presents Special Issues that shed light on current and topical areas in cancer research. Cancer Letters is highly interested in various fundamental aspects that can cater to a diverse readership. These areas include the molecular genetics and cell biology of cancer, radiation biology, molecular pathology, hormones and cancer, viral oncology, metastasis, and chemoprevention. The journal actively focuses on experimental therapeutics, particularly the advancement of targeted therapies for personalized cancer medicine, such as metronomic chemotherapy. By publishing groundbreaking research and promoting advancements in cancer treatments, Cancer Letters aims to actively contribute to the fight against cancer and the improvement of patient outcomes.