Associations between leisure time, non-leisure time physical activity, and kidney function in Japanese adults: a cross-sectional study.

IF 2.2 4区 医学 Q2 UROLOGY & NEPHROLOGY
Ippei Chiba, Naoki Nakaya, Mana Kogure, Rieko Hatanaka, Kumi Nakaya, Sayuri Tokioka, Tomohiro Nakamura, Satoshi Nagaie, Soichi Ogishima, Taku Obara, Toshimi Sato, Nobuo Fuse, Yoko Izumi, Shinichi Kuriyama, Atsushi Hozawa
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引用次数: 0

Abstract

Background: Chronic kidney disease (CKD) contributes to decreased life expectancy. We examined the association between leisure-time physical activity (LTPA), non-leisure-time physical activity (non-LTPA) and kidney function.

Methods: This was a cross-sectional study including 32 162 community-dwelling adults aged ≥ 20 years from the Tohoku Medical MegaBank community-based cohort study. Kidney function was evaluated using cystatin C-based estimated glomerular filtration rate (eGFR) as well as self-reported LTPA and non-LTPA. CKD was defined as either eGFR decline (≤ 60 mL/min/1.73 m2) or presence of albuminuria (albumin-creatinine ≥ 30 mg/g). The association between domain-specific physical activity and kidney function, and CKD prevalence was examined using multivariable-adjusted ordinary least squares and modified Poisson models.

Results: The mean eGFR was 98.1 (± 13.2) mL/min/1.73 m2. 3 185 (9.9%) participants were classified as having CKD. The mean LTPA and non-LTPA levels were 2.9 (± 4.2) and 16.6 (± 14.2) METs-hour/day, respectively. For LTPA, in the adjusted model, the quartile groups with higher levels had a higher kidney function (β, 0.36; 95% confidence intervals [CI], [0.06, 0.66]; p = 0.019 for the 2nd quartile, β, 0.82; 95% CI, [0.51, 1.14]; p < 0.001 for the 3rd quartile, and β, 1.16; 95% CI, [0.83, 1.49]; p < 0.001 for the 4th quartile), whereas there were no apparent associations for prevalence of CKD. For non-LTPA, 4th quartile was associated with decreased eGFR (β, -0.42; 95% CI, [-0.72, -0.11]; p = 0.007) and higher prevalence of CKD prevalence (Prevalence ratio, 1.12; 95% CI, [1.02, 1.24]; p = 0.022). These associations with kidney function remained consistent in the subgroup analyses divided by demographic and biological variables.

Conclusions: We observed a positive association between higher LTPA levels and better kidney function, but not association with CKD prevalence. In contrast, higher non-LTPA was negatively associated with both kidney function and CKD prevalence. These findings suggest that promoting LTPA is beneficial for kidney function.

日本成年人闲暇时间、非闲暇时间体育活动与肾功能之间的关系:一项横断面研究。
背景:慢性肾脏病(CKD)会导致预期寿命缩短。我们研究了闲暇时间体育活动(LTPA)、非闲暇时间体育活动(Non-LTPA)与肾功能之间的关系:这是一项横断面研究,包括来自东北医疗 MegaBank 社区队列研究的 32 162 名年龄≥ 20 岁的社区成年人。采用基于胱抑素 C 的肾小球滤过率(eGFR)估算值以及自我报告的长程肾衰竭和非长程肾衰竭来评估肾功能。eGFR 下降(≤ 60 mL/min/1.73 m2)或出现白蛋白尿(白蛋白-肌酐≥ 30 mg/g)即为慢性肾功能衰竭。采用多变量调整普通最小二乘法和修正泊松模型研究了特定领域体力活动与肾功能和慢性肾功能衰竭患病率之间的关系:平均 eGFR 为 98.1 (± 13.2) mL/min/1.73 m2。3 185 人(9.9%)被归类为患有慢性肾功能衰竭。LTPA和非LTPA的平均水平分别为2.9 (± 4.2) METs-小时/天和16.6 (± 14.2) METs-小时/天。在调整模型中,LTPA 水平较高的四分位组肾功能较好(β,0.36;95% 置信区间 [CI],[0.06, 0.66];第 2 个四分位组 p = 0.019,β,0.82;95% 置信区间 [CI],[0.51, 1.14];p):我们观察到,LTPA 水平越高,肾功能越好,但与 CKD 患病率无关。相反,较高的非LTPA水平与肾功能和慢性肾脏病患病率均呈负相关。这些研究结果表明,促进 LTPA 对肾功能有益。
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来源期刊
BMC Nephrology
BMC Nephrology UROLOGY & NEPHROLOGY-
CiteScore
4.30
自引率
0.00%
发文量
375
审稿时长
3-8 weeks
期刊介绍: BMC Nephrology is an open access journal publishing original peer-reviewed research articles in all aspects of the prevention, diagnosis and management of kidney and associated disorders, as well as related molecular genetics, pathophysiology, and epidemiology.
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