Molecular significance of circRNAs in malignant lymphoproliferative disorders: pathogenesis and novel biomarkers or therapeutic targets.

IF 3.6 3区医学 Q2 ONCOLOGY

American journal of cancer research Pub Date : 2024-09-25 eCollection Date: 2024-01-01 DOI:10.62347/KMWB5164

Bo-Yang Long, Yan Wang, Shu-Hong Hao, Guang Shi

引用次数: 0

Abstract

Recent studies have shown that circular RNAs (CircRNAs) have the novel functions and molecular mechanisms in the pathogenesis of malignant diseases. CircRNAs have been found to be associated with the occurrence and development of lymphoproliferative diseases, impacting on lymphocyte proliferation. This article provides a review of the pathogenesis of circRNAs in malignant lymphoproliferative disorders, focusing on conditions such as acute lymphocytic leukemia (ALL), chronic lymphocytic leukemia (CLL), and lymphoma. Additionally, it discusses the potential value of circRNAs as novel biomarkers or therapeutic targets in these disorders.

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恶性淋巴细胞增生性疾病中 circRNAs 的分子意义：发病机制和新型生物标记物或治疗靶标。

最近的研究表明，环状 RNA（CircRNA）在恶性疾病的发病机制中具有新的功能和分子机制。研究发现，循环 RNA 与淋巴增殖性疾病的发生和发展有关，影响淋巴细胞的增殖。本文综述了循环RNA在恶性淋巴细胞增生性疾病中的发病机制，重点探讨了急性淋巴细胞白血病（ALL）、慢性淋巴细胞白血病（CLL）和淋巴瘤等疾病。此外，报告还讨论了 circRNAs 作为新型生物标记物或治疗靶点在这些疾病中的潜在价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of cancer research ONCOLOGY-

自引率

3.80%

发文量

263

期刊介绍： The American Journal of Cancer Research (AJCR) (ISSN 2156-6976), is an independent open access, online only journal to facilitate rapid dissemination of novel discoveries in basic science and treatment of cancer. It was founded by a group of scientists for cancer research and clinical academic oncologists from around the world, who are devoted to the promotion and advancement of our understanding of the cancer and its treatment. The scope of AJCR is intended to encompass that of multi-disciplinary researchers from any scientific discipline where the primary focus of the research is to increase and integrate knowledge about etiology and molecular mechanisms of carcinogenesis with the ultimate aim of advancing the cure and prevention of this increasingly devastating disease. To achieve these aims AJCR will publish review articles, original articles and new techniques in cancer research and therapy. It will also publish hypothesis, case reports and letter to the editor. Unlike most other open access online journals, AJCR will keep most of the traditional features of paper print that we are all familiar with, such as continuous volume, issue numbers, as well as continuous page numbers to retain our comfortable familiarity towards an academic journal.