Production and radiochemical separation of Tb-161 as a feasible beta therapeutic radioisotope from reactor irradiated Gd target

IF 3.8 2区化学 Q1 BIOCHEMICAL RESEARCH METHODS

Journal of Chromatography A Pub Date : 2024-10-12 DOI:10.1016/j.chroma.2024.465439

Mohamed A. Gizawy , A.M. Shahr El-Din , E.H. Borai , Nader M.A. Mohamed

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引用次数: 0

Abstract

Terbium-161 (¹⁶¹Tb) is a promising therapeutic radionuclide that has gained significant attention in the field of nuclear medicine in recent years. ¹⁶¹Tb has several favorable characteristics that make it a valuable candidate for targeted radionuclide therapy. The production of No-carrier-added ¹⁶¹Tb was carried out by the neutron activation of natural gadolinium target in the Egyptian Second Research Reactor (ETRR-2) at a thermal neutron flux position of 1.8 × 10¹⁴ ncm^-2s^-1. The radioactivities of ¹⁶¹Tb as well as coproduced Gd radioimpurities were computed theoretically by the MCNPX2.7.0 code and verified by actual measurements, where accepted discrepancies were obtained. The purification of ¹⁶¹Tb from irradiated Gd target was developed by Chelex-100 resin. The elution performance was studied using different eluents, and 0.1 M HNO₃ was found to be the best medium to obtain a high separation efficiency of more than 92% in a short time. The eluted ¹⁶¹Tb was of high chemical, radiochemical, and radionuclidic purities, indicating its potential for effective application in radiopharmaceutical preparation.

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从反应堆辐照过的钆靶中生产出 Tb-161 并进行放射化学分离，将其作为一种可行的β治疗放射性同位素。

铽-161（161Tb）是一种很有前途的治疗用放射性核素，近年来在核医学领域备受关注。161Tb 具有多种有利特性，是放射性核素靶向治疗的重要候选材料。埃及第二研究堆（ETRR-2）在 1.8 × 1014 ncm-2s-1 的热中子通量条件下，通过对天然钆靶进行中子活化，生产出了无载流子添加的 161Tb。通过 MCNPX2.7.0 代码对 161Tb 以及共生钆放射性杂质的放射性活度进行了理论计算，并通过实际测量进行了验证，得到了可接受的差异。利用 Chelex-100 树脂开发了从辐照钆靶中提纯 161Tb 的方法。使用不同的洗脱剂对洗脱性能进行了研究，发现 0.1 M HNO3 是最佳介质，可在短时间内获得 92% 以上的高分离效率。洗脱出的 161Tb 化学纯度、放射化学纯度和放射性核素纯度都很高，表明其有望在放射性药物制备中得到有效应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Chromatography A 化学-分析化学

CiteScore

7.90

自引率

14.60%

发文量

742

审稿时长

45 days

期刊介绍： The Journal of Chromatography A provides a forum for the publication of original research and critical reviews on all aspects of fundamental and applied separation science. The scope of the journal includes chromatography and related techniques, electromigration techniques (e.g. electrophoresis, electrochromatography), hyphenated and other multi-dimensional techniques, sample preparation, and detection methods such as mass spectrometry. Contributions consist mainly of research papers dealing with the theory of separation methods, instrumental developments and analytical and preparative applications of general interest.