Access to Vinyl Gem-Difluorinated Cyclopropanes Via Photopromoted Palladium-Catalyzed Heck Reaction.

IF 3.5 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - An Asian Journal Pub Date : 2024-10-17 DOI:10.1002/asia.202400775

Bin Li, Qiu-Shi Feng, Jia-Li Yuan, Ying Xia

引用次数: 0

Abstract

A photopromoted Pd-catalyzed Heck reaction of gem-difluorocyclopropyl bromides (DFCBs) with styrenes to deliver vinyl gem-difluorinated cyclopropanes (VDFCs) under mild conditions has been developed. The reaction demonstrates good functional group compatibility while providing high E/Z ratio of the products. Furthermore, the desired VDFCs can be easily transformed into fluorinated cyclic/acyclic architectures, which may broaden its applications in organic synthesis.

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通过光促进钯催化赫克反应获得乙烯基二氟化环丙烷。

本研究开发了一种光催化钯催化的宝石二氟环丙基溴（DFCBs）与苯乙烯的赫克反应，从而在温和的条件下生成乙烯基宝石二氟环丙烷（VDFCs）。该反应具有良好的官能团兼容性，同时产物的 E/Z 比值较高。此外，所需的 VDFCs 可以很容易地转化为含氟环状/环状结构，这可能会拓宽其在有机合成中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - An Asian Journal 化学-化学综合

CiteScore

7.00

自引率

2.40%

发文量

535

审稿时长

1.3 months

期刊介绍： Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics. Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews. A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal. Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).