The potential of xanthotoxin in the treatment of cognitive disorders: current insights and future perspectives

IF 3.4 Q2 PHARMACOLOGY & PHARMACY

Future Journal of Pharmaceutical Sciences Pub Date : 2024-10-22 DOI:10.1186/s43094-024-00717-y

Uma Agarwal, Arzoo Pannu, Rajiv Kumar Tonk, Puja Jaiswal, Kajal Jain

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Abstract

Background

The prevalence of cognitive diseases, including Alzheimer’s disease and other forms of dementia, poses a significant global health challenge due to the limited availability of effective therapeutic options. Recent years have witnessed a growing emphasis in research on the exploration of natural compounds and their derivatives as prospective therapeutic agents for cognitive impairments.

Main body Xanthotoxin, a furanocoumarin compound derived from botanical sources, exhibits promising therapeutic promise in several neurological conditions such as depression, neuronal inflammation, Alzheimer’s disease, vascular cognitive impairment, epilepsy, and Parkinson’s disease. This potential stems from its notable neuroprotective, antioxidant, and anti-inflammatory characteristics. The present study offers a comprehensive examination of the acquisition of XAT from both natural sources and synthetic means. It delves into the significance of XAT in the treatment of cognitive disorders and delineates potential avenues for future research in the domain of XAT and cognitive disorders.

Conclusion

Ongoing research and advancements in the field of XAT have the potential to enhance its use as a potent therapeutic intervention for cognitive impairments, consequently enhancing the holistic welfare of those afflicted by these incapacitating disorders.

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黄毒素在治疗认知障碍方面的潜力：当前见解与未来展望

背景由于有效的治疗方案有限，认知疾病（包括阿尔茨海默病和其他形式的痴呆症）的流行对全球健康构成了重大挑战。黄毒素是一种从植物中提取的呋喃香豆素化合物，在抑郁症、神经元炎症、阿尔茨海默病、血管性认知障碍、癫痫和帕金森病等多种神经系统疾病中具有良好的治疗前景。这种潜力源于其显著的神经保护、抗氧化和抗炎特性。本研究全面考察了从天然来源和合成方法中获取 XAT 的情况。本研究深入探讨了 XAT 在治疗认知障碍方面的重要意义，并为未来在 XAT 和认知障碍领域的研究指明了潜在的途径。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Future Journal of Pharmaceutical Sciences PHARMACOLOGY & PHARMACY-

自引率

0.00%

发文量

审稿时长

23 weeks

期刊介绍： Future Journal of Pharmaceutical Sciences (FJPS) is the official journal of the Future University in Egypt. It is a peer-reviewed, open access journal which publishes original research articles, review articles and case studies on all aspects of pharmaceutical sciences and technologies, pharmacy practice and related clinical aspects, and pharmacy education. The journal publishes articles covering developments in drug absorption and metabolism, pharmacokinetics and dynamics, drug delivery systems, drug targeting and nano-technology. It also covers development of new systems, methods and techniques in pharmacy education and practice. The scope of the journal also extends to cover advancements in toxicology, cell and molecular biology, biomedical research, clinical and pharmaceutical microbiology, pharmaceutical biotechnology, medicinal chemistry, phytochemistry and nutraceuticals.