Targeting proteins to lysosomes with a chemical inducer of arginine methylation

IF 12.9 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Nature chemical biology Pub Date : 2024-10-22 DOI:10.1038/s41589-024-01744-9

引用次数: 0

Abstract

Arginine methylation acts as a signal for intracellular proteins to be degraded in lysosomes. We developed methylarginine targeting chimera (MrTAC), a chemical tool that induces proximity with protein arginine N-methyltransferase 1 (PRMT1) to trigger arginine methylation and thus targeted protein degradation in lysosomes.

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用精氨酸甲基化化学诱导剂将蛋白质定向到溶酶体

精氨酸甲基化是细胞内蛋白质在溶酶体中降解的信号。我们开发了甲基精氨酸靶向嵌合体（Methylarginine targeting chimera，MrTAC），它是一种化学工具，能诱导精氨酸 N-甲基转移酶 1（Protein arginine N-methyltransferase 1，PRMT1）接近，引发精氨酸甲基化，从而在溶酶体中靶向降解蛋白质。

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来源期刊

Nature chemical biology 生物-生化与分子生物学

CiteScore

23.90

自引率

1.40%

发文量

238

审稿时长

12 months

期刊介绍： Nature Chemical Biology stands as an esteemed international monthly journal, offering a prominent platform for the chemical biology community to showcase top-tier original research and commentary. Operating at the crossroads of chemistry, biology, and related disciplines, chemical biology utilizes scientific ideas and approaches to comprehend and manipulate biological systems with molecular precision. The journal embraces contributions from the growing community of chemical biologists, encompassing insights from chemists applying principles and tools to biological inquiries and biologists striving to comprehend and control molecular-level biological processes. We prioritize studies unveiling significant conceptual or practical advancements in areas where chemistry and biology intersect, emphasizing basic research, especially those reporting novel chemical or biological tools and offering profound molecular-level insights into underlying biological mechanisms. Nature Chemical Biology also welcomes manuscripts describing applied molecular studies at the chemistry-biology interface due to the broad utility of chemical biology approaches in manipulating or engineering biological systems. Irrespective of scientific focus, we actively seek submissions that creatively blend chemistry and biology, particularly those providing substantial conceptual or methodological breakthroughs with the potential to open innovative research avenues. The journal maintains a robust and impartial review process, emphasizing thorough chemical and biological characterization.