State of the art in organometallic ruthenium metallodrugs for breast cancer treatment: Advances and innovations

IF 20.3 1区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Coordination Chemistry Reviews Pub Date : 2024-10-22 DOI:10.1016/j.ccr.2024.216252

Elena Domínguez-Jurado , Agustín Lara-Sánchez , Iván Bravo , Alberto Ocaña , Carlos Alonso-Moreno

引用次数: 0

Abstract

Cancer is a major health concern and a leading cause of death worldwide. Among all cancer types, breast cancer has the highest incidence rate. The treatment of breast cancer encompasses the use of different drugs, with ruthenium metallodrugs emerging as promising alternatives to platinum derivatives. In this context, organometallic ruthenium(II) compounds are currently the most widely explored.

This review compiles all the organometallic ruthenium compounds described in the literature to date for the treatment of breast cancer. Additionally, it covers the use of ruthenium-based metallodrugs in combination therapy, phototherapy, and nanotechnology.

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有机金属钌金属药物治疗乳腺癌的最新进展：进展与创新

癌症是一个重大的健康问题，也是全球死亡的主要原因。在所有癌症类型中，乳腺癌的发病率最高。乳腺癌的治疗包括使用不同的药物，而钌金属药物作为铂衍生物的替代品正在崭露头角。在这方面，有机金属钌（II）化合物是目前研究最为广泛的。本综述汇编了迄今为止文献中描述的用于治疗乳腺癌的所有有机金属钌化合物。此外，它还涉及钌基金属药物在联合治疗、光疗和纳米技术中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Coordination Chemistry Reviews 化学-无机化学与核化学

CiteScore

34.30

自引率

5.30%

发文量

457

审稿时长

54 days

期刊介绍： Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers. The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.