Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2024-10-20 DOI:10.1002/alz.14283

Wan-Ping Lee, Seung Hoan Choi, Margaret G. Shea, Po-Liang Cheng, Beth A. Dombroski, Achilleas N. Pitsillides, Nancy L. Heard-Costa, Hui Wang, Katia Bulekova, Amanda B. Kuzma, Yuk Yee Leung, John J. Farrell, Honghuang Lin, Brian W. Kunkle, Adam Naj, Elizabeth E. Blue, Frederick Nusetor, Dongyu Wang, Eric Boerwinkle, William S. Bush, Xiaoling Zhang, Philip L. De Jager, Josée Dupuis, Lindsay A. Farrer, Myriam Fornage, Eden Martin, Margaret Pericak-Vance, Sudha Seshadri, Ellen M. Wijsman, Li-San Wang, , Gerard D. Schellenberg, Anita L. Destefano, Jonathan L. Haines, Gina M. Peloso

引用次数: 0

Abstract

Alzheimer's disease (AD) is a common disorder of the elderly that is both highly heritable and genetically heterogeneous.

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通过阿尔茨海默病测序项目的全基因组测序，13,000 多名不同个体中的常见和罕见变异与阿尔茨海默病的关系

阿尔茨海默病（AD）是一种常见的老年疾病，具有高度遗传性和基因异质性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.