Functionally Separate Populations of Ventromedial Hypothalamic Neurons in Obesity and Diabetes

IF 6.2 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Pub Date : 2024-10-17 DOI:10.2337/dbi24-0011

Jonathan N. Flak

引用次数: 0

Abstract

The Ventromedial hypothalamic nucleus (VMN) maintains healthy metabolic function through several important roles. Collectively, homeostasis is maintained via intermingled cells within the VMN that raise blood glucose, lower blood glucose, and stimulate energy expenditure when needed. This perspective discusses the defining factors for the VMN cell types that govern distinct functions induced by the VMN, particularly in relation to energy balance and blood glucose levels. Special attention is given to distinct features of VMN cells responsible for these processes. Finally, these topics are reviewed in the context of research funded by the Pathway to Stop Diabetes initiative, highlighting key findings and current unresolved questions for future investigations.

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肥胖症和糖尿病患者下丘脑中功能独立的神经元群

下丘脑中内侧核（VMN）通过发挥几个重要作用来维持健康的代谢功能。总体而言，平衡是通过 VMN 内相互混合的细胞来维持的，这些细胞可在需要时升高血糖、降低血糖和刺激能量消耗。本视角讨论了 VMN 细胞类型的决定性因素，这些因素支配着 VMN 所诱导的不同功能，尤其是与能量平衡和血糖水平有关的功能。其中特别关注了负责这些过程的 VMN 细胞的独特特征。最后，本文结合 "通往糖尿病终结之路 "计划资助的研究对这些主题进行了综述，重点介绍了主要发现和目前尚未解决的问题，供今后研究参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.