KSCN-mediated one-pot thiocyanation tandem cyclization of enaminones: a facile access to 2-amino/imino thiazolo fused chromone and coumarin frameworks

Abstract

A rapid metal-free approach describing one-pot thiocyanation of chromone and coumarin enabling tandem cyclization via potassium thiocyanate as a sulfur surrogate was unveiled. Interestingly, this enaminone-mediated protocol facilitated straightforward access to medicinally significant 2-amino/imino thiazolo fused chromone and coumarin frameworks. This methodology provided good atom-economy, remarkable functional group tolerance, and scalability. Alongside establishing a wide substrate scope, it also provided a feasible scalability up to gram scale.