Propofol-alone sedative efficacy in observational biliopancreatic endoscopic ultrasound

IF 1.4 Q4 GASTROENTEROLOGY & HEPATOLOGY

DEN open Pub Date : 2024-10-17 DOI:10.1002/deo2.70025

Hisaki Kato, Yuki Kawasaki, Kazuya Sumi, Yuki Shibata, Norihiro Nomura, Jun Ushio, Junichi Eguchi, Takayoshi Ito, Haruhiro Inoue

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引用次数: 0

Abstract

Objectives

Appropriate sedative and analgesic selection is essential to reduce patient discomfort and body movement to safely conduct endoscopic ultrasonography (EUS). However, few cases have examined sedation with propofol in EUS, and few studies the need for combined analgesia. In this study, we retrospectively evaluated the usefulness and safety of propofol without analgesics for sedation in biliopancreatic observational EUS.

Methods

This single-center retrospective study included 516 observational biliopancreatic EUS procedures using propofol alone performed between April 2021 and March 2023. The primary and secondary endpoints were the observational biliopancreatic EUS results obtained with propofol alone and adverse event occurrence, respectively.

Results

The median examination time and total propofol dose were 22 (range: 10–67) min and 186.5 (range: 50–501) mg, respectively. The median starting Richmond Agitation-Sedation Scale and Visual Analog Scale scores were −5 (range: −5–1) and 0 (range: 0–10), respectively. The median recovery time was 22 (range: 5–80) min. Adverse events occurred in 60 (11.6%) patients. Trainee-performed examination (odds ratio [OR] 3.52, 95% confidence interval [CI]: 1.63–7.60, p = 0.0014) and examination length (>22 min; OR 1.67, 95% CI: 0.95–2.92, p = 0.07) were risk factors for adverse events.

High body mass index (OR 1.87, 95% CI: 1.10–3.16, p = 0.02) and extended examination time (OR 4.23, 95% CI: 2.08–8. 57, p < 0.001) were risk factors for delayed recovery.

Conclusions

During observational biliopancreatic EUS, propofol is useful as a single sedative and offers high patient satisfaction and relative safety.

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在观察性胆胰内镜超声检查中单独使用丙泊酚的镇静效果

目的选择适当的镇静剂和镇痛剂对于减少患者的不适感和身体移动以安全进行内窥镜超声波检查（EUS）至关重要。然而，在 EUS 中使用异丙酚镇静的病例很少，对是否需要联合镇痛的研究也很少。在本研究中，我们回顾性评估了在胆胰观察 EUS 中使用异丙酚镇静而不使用镇痛剂的实用性和安全性。方法这项单中心回顾性研究纳入了 2021 年 4 月至 2023 年 3 月期间进行的 516 例仅使用异丙酚的胆胰 EUS 观察手术。主要终点和次要终点分别为观察性胆管胰腺 EUS 结果和不良事件发生率。结果检查时间和异丙酚总剂量的中位数分别为 22 分钟（范围：10-67）和 186.5 毫克（范围：50-501）。里士满躁动不安量表和视觉模拟量表的起始评分中位数分别为-5（范围：-5-1）和0（范围：0-10）。恢复时间中位数为 22 分钟（范围：5-80 分钟）。60名患者（11.6%）出现了不良反应。由受训人员进行的检查（几率比 [OR] 3.52，95% 置信区间 [CI]：1.63-7.60，p = 0.0014）和检查时间（>22 分钟；OR 1.67，95% CI：0.95-2.92，p = 0.07）是不良事件的风险因素。高体重指数（OR 1.87，95% CI：1.10-3.16，p = 0.02）和延长检查时间（OR 4.23，95% CI：2.08-8.57，p <0.001）是延迟恢复的危险因素。结论在观察性胆管胰腺 EUS 期间，异丙酚作为单一镇静剂非常有用，患者满意度高且相对安全。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

DEN open

CiteScore

1.30

自引率

0.00%

发文量