Inflammatory role of S100A8/A9 in the central nervous system non-neoplastic diseases

IF 3.5 3区医学 Q2 NEUROSCIENCES

Brain Research Bulletin Pub Date : 2024-10-11 DOI:10.1016/j.brainresbull.2024.111100

Qi Tian , Zhijie Li , Ziang Yan , Shengming Jiang , Xincan Zhao , Lei Wang , Mingchang Li

{"title":"Inflammatory role of S100A8/A9 in the central nervous system non-neoplastic diseases","authors":"Qi Tian , Zhijie Li , Ziang Yan , Shengming Jiang , Xincan Zhao , Lei Wang , Mingchang Li","doi":"10.1016/j.brainresbull.2024.111100","DOIUrl":null,"url":null,"abstract":"<div><div>S100A8 (MRP8) and S100A9 (MRP14) are critical mediators of the inflammatory response; they are usually present as heterodimers because of the instability of homodimers. Studies have demonstrated that S100A8/A9 expression is significantly upregulated in several central nervous system (CNS) diseases. S100A8/A9 is actively released by neutrophils and monocytes; it plays a key role in regulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion during inflammation. Additionally, S100A8/A9 can be used as a diagnostic biomarker for several CNS diseases and as a predictor of therapeutic response to inflammation-related diseases. In this work, we reviewed our current understanding of S100A8/A9 overexpression in inflammation and its importance in the development and progression of CNS inflammatory diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and stroke, and the functional roles and therapeutic applications of S100A8/A9 in these diseases. Finally, we discussed the current barriers and future research directions of S100A8/A9 in CNS diseases.</div></div>","PeriodicalId":9302,"journal":{"name":"Brain Research Bulletin","volume":"218 ","pages":"Article 111100"},"PeriodicalIF":3.5000,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brain Research Bulletin","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S036192302400234X","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"NEUROSCIENCES","Score":null,"Total":0}

引用次数: 0

Abstract

S100A8 (MRP8) and S100A9 (MRP14) are critical mediators of the inflammatory response; they are usually present as heterodimers because of the instability of homodimers. Studies have demonstrated that S100A8/A9 expression is significantly upregulated in several central nervous system (CNS) diseases. S100A8/A9 is actively released by neutrophils and monocytes; it plays a key role in regulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion during inflammation. Additionally, S100A8/A9 can be used as a diagnostic biomarker for several CNS diseases and as a predictor of therapeutic response to inflammation-related diseases. In this work, we reviewed our current understanding of S100A8/A9 overexpression in inflammation and its importance in the development and progression of CNS inflammatory diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and stroke, and the functional roles and therapeutic applications of S100A8/A9 in these diseases. Finally, we discussed the current barriers and future research directions of S100A8/A9 in CNS diseases.

查看原文本刊更多论文

S100A8/A9 在中枢神经系统非肿瘤性疾病中的炎症作用

S100A8（MRP8）和 S100A9（MRP14）是炎症反应的关键介质；由于同源二聚体的不稳定性，它们通常以异源二聚体的形式存在。研究表明，在几种中枢神经系统（CNS）疾病中，S100A8/A9 的表达明显上调。S100A8/A9 由中性粒细胞和单核细胞主动释放；在炎症反应中，它通过刺激白细胞募集和诱导细胞因子分泌，在调节炎症反应中发挥着关键作用。此外，S100A8/A9 还可用作多种中枢神经系统疾病的诊断生物标志物，以及炎症相关疾病治疗反应的预测因子。在这项工作中，我们回顾了我们目前对 S100A8/A9 在炎症中的过表达及其在阿尔茨海默病（AD）、帕金森病（PD）、多发性硬化症（MS）和中风等中枢神经系统炎症性疾病的发生和发展中的重要性的理解，以及 S100A8/A9 在这些疾病中的功能作用和治疗应用。最后，我们讨论了 S100A8/A9 在中枢神经系统疾病中的现有障碍和未来研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.