Aortic aneurysm: Correlations with phenotypes associated with connective tissue dysplasia

IF 2.9 4区医学 Q2 PERIPHERAL VASCULAR DISEASE

Microvascular research Pub Date : 2024-10-12 DOI:10.1016/j.mvr.2024.104754

Maria Roslik , Yury Zharikov , Andzhela Vovkogon , Nataliya Zharova , André Pontes-Silva , Tatiana Zharikova

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引用次数: 0

Abstract

An aortic aneurysm is a localized enlargement that exceeds the normal diameter of the vessel by 50 %, posing a risk due to the likelihood of rupture. The cause of aortic aneurysm, especially in young people, is connective tissue dysplasia, a condition characterized by defects in the assembly of collagen and elastin proteins, leading to changes in elastic properties and disruption of the formation of organs and their systems. The article presents data confirming the relationship between many morphological manifestations of connective tissue dysplasia (e.g., funnel-shaped deformation of the sternum, scoliosis of the thoracic spine, abdominal hernias, arterial tortuosity, striae of atypical localization) and the risk of aortic aneurysm formation. The literature suggests that the identified combinations of some external manifestations of connective tissue dysplasia deserve special attention and may be constitutional markers for the possible development of aortic aneurysm, which is a promising direction for further research in this area.

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主动脉瘤：与结缔组织发育不良相关表型的关系

主动脉瘤是一种局部扩大的血管，其直径超过正常直径的 50%，有破裂的危险。主动脉瘤（尤其是年轻人）的病因是结缔组织发育不良，这种疾病的特点是胶原蛋白和弹性蛋白的装配缺陷，导致弹性特性发生变化，并破坏器官及其系统的形成。文章提供的数据证实了结缔组织发育不良的多种形态表现（如胸骨漏斗状变形、胸椎侧弯、腹部疝气、动脉迂曲、不典型定位的条纹）与主动脉瘤形成风险之间的关系。文献表明，已发现的结缔组织发育不良的一些外部表现的组合值得特别关注，它们可能是主动脉瘤可能发展的宪法标志，这也是这一领域有希望的进一步研究方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microvascular research 医学-外周血管病

CiteScore

6.00

自引率

3.20%

发文量

158

审稿时长

43 days

期刊介绍： Microvascular Research is dedicated to the dissemination of fundamental information related to the microvascular field. Full-length articles presenting the results of original research and brief communications are featured. Research Areas include: • Angiogenesis • Biochemistry • Bioengineering • Biomathematics • Biophysics • Cancer • Circulatory homeostasis • Comparative physiology • Drug delivery • Neuropharmacology • Microvascular pathology • Rheology • Tissue Engineering.