The neuroscience of mental illness: Building toward the future

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2024-10-17 DOI:10.1016/j.cell.2024.09.028

Joshua A. Gordon, Kafui Dzirasa, Frederike H. Petzschner

引用次数: 0

Abstract

Mental illnesses arise from dysfunction in the brain. Although numerous extraneural factors influence these illnesses, ultimately, it is the science of the brain that will lead to novel therapies. Meanwhile, our understanding of this complex organ is incomplete, leading to the oft-repeated trope that neuroscience has yet to make significant contributions to the care of individuals with mental illnesses. This review seeks to counter this narrative, using specific examples of how neuroscientific advances have contributed to progress in mental health care in the past and how current achievements set the stage for further progress in the future.

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精神疾病的神经科学：面向未来

精神疾病源于大脑功能失调。虽然影响这些疾病的外部因素很多，但最终还是要靠大脑科学才能找到新的疗法。与此同时，我们对这一复杂器官的了解却并不全面，这就导致了一种经常被重复的说法，即神经科学尚未对精神疾病患者的治疗做出重大贡献。这篇综述试图反驳这种说法，通过具体实例说明神经科学的进步在过去是如何推动精神疾病治疗取得进展的，以及当前的成就又是如何为未来的进一步发展奠定基础的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.