IL-1 signaling in aging and cancer: An inflammaging feedback loop unveiled

IF 48.8 1区医学 Q1 CELL BIOLOGY

Cancer Cell Pub Date : 2024-10-17 DOI:10.1016/j.ccell.2024.09.015

Mingyong Liu, Bo Zhu, Qi-Jing Li

引用次数: 0

Abstract

In a Science paper, Park et al. identified interleukin (IL)-1α as a key driver of positive feedback in inflammaging, linking aging-associated downregulation of DNMT3A to increased IL-1α production in lung myeloid cells. This triggers emergency myelopoiesis in the bone marrow, amplifying myeloid-mediated intratumoral immunosuppression for tumor progression in aged mice.

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IL-1 信号在衰老和癌症中的作用：揭示炎症反馈回路

在一篇科学论文中，Park 等人发现白细胞介素（IL）-1α 是炎症正反馈的一个关键驱动因素，它将衰老相关的 DNMT3A 下调与肺髓细胞中 IL-1α 生成的增加联系起来。这引发了骨髓中的紧急骨髓造血，扩大了髓细胞介导的肿瘤内免疫抑制，促进了老年小鼠的肿瘤进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Cell 医学-肿瘤学

CiteScore

55.20

自引率

1.20%

发文量

179

审稿时长

4-8 weeks

期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.