Exploring the therapeutic potential of Cedrelopsis grevei Baill. (Rutaceae): A comprehensive review on the traditional uses, phytochemistry, pharmacological properties and essential oils

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-10-16 DOI:10.1016/j.sajb.2024.10.007

Thanyani Emelton Ramadwa , Fikile Nelly Makhubu

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引用次数: 0

Abstract

Cedrelopsis grevei Baill (Rutaceae) is an indigenous species of Madagascar and widely used in ethnomedicine. Its bark, stem, leaves, and essential oils have been traditionally used as aphrodisiacs and for treating various illnesses, such as fever, malaria, inflammatory disorders, diabetes, fatigue, and hypertension. The purpose of this comprehensive review is to offer guidance for future studies and possible applications by summarizing the current developments to date regarding studies on C. grevei essential oils, isolated phytochemicals, pharmacological properties, and in vivo studies. Data on C. grevei were gathered using the following databases: Web of Science, Science Direct, Scopus, Google Scholar, SciFinder, Wiley online, SpringerLink, and PubMed. It has been reported that C. grevei contains triterpenoid derivatives, coumarins, acetophenones, chromones, and limonoids. Its essential oils, mainly composed of sesquiterpene hydrocarbons, oxygenated sesquiterpenes, oxygenated monoterpenes and monoterpene hydrocarbons, includes 160 identified constituents of essential oils and about 29 other compounds from various plant parts. This plant species exhibits different pharmacological activities, such as antimicrobial, antimalarial, antioxidant, anti-inflammatory, and antiproliferative against cancer cell lines. Ex vivo and in vivo studies have explored its vasodilation and cardiovascular effects. The review showed that the pharmacological activity of C. grevei extracts, fractions, and isolated compounds support the use of this plant in traditional medicine for a variety of illnesses. However, more studies are required to be done on scientific and clinical aspects to support its therapeutic applications. Further studies on chronic toxicity and efficacy in animal models are necessary to confirm its therapeutic potential and ensure safety for future clinical trials.

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探索 Cedrelopsis grevei Baill.(芸香科）的治疗潜力：关于传统用途、植物化学、药理特性和精油的全面综述

Cedrelopsis grevei Baill（芸香科）是马达加斯加的本土物种，被广泛用于民族医药中。其树皮、茎、叶和精油历来被用作壮阳药和治疗各种疾病，如发烧、疟疾、炎症、糖尿病、疲劳和高血压。本综述旨在通过总结迄今为止有关灰树花精油、分离植物化学物质、药理特性和体内研究的最新进展，为今后的研究和可能的应用提供指导。有关 C. grevei 的数据是通过以下数据库收集的：Web of Science、Science Direct、Scopus、Google Scholar、SciFinder、Wiley online、SpringerLink 和 PubMed。据报道，灰树皮含有三萜类衍生物、香豆素、苯乙酮、色酮和类柠檬酸。其精油主要由倍半萜碳氢化合物、含氧倍半萜、含氧单萜和单萜碳氢化合物组成，包括 160 种已确定的精油成分和来自不同植物部位的约 29 种其他化合物。这种植物具有不同的药理活性，如抗菌、抗疟、抗氧化、抗炎和抗癌细胞增殖。体内外研究探讨了它对血管扩张和心血管的作用。综述显示，灰树花提取物、馏分和分离化合物的药理活性支持将这种植物用于治疗多种疾病的传统医药中。不过，还需要在科学和临床方面开展更多研究，以支持其治疗应用。有必要进一步研究动物模型的慢性毒性和疗效，以确认其治疗潜力，并确保未来临床试验的安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464