Allylation of aldehydes with various allylation agents

Abstract

Allylation of aldehydes is one of the most important organic transformations that helps in the synthesis of compounds with special skeletons with unique medicinal properties. From 2001 to 2024, extensive research has been done in this field using different catalysts, and this organic technology is maturing. Most of the studies are based on the use of different catalysts and various ligands to obtain maximum diastereoselectivity and enantioselectivity. In this review, we have summarized recent research on the allylation of aldehydes using various allylation agents, including allyl acetate, allyl trichlorosilane, allyltributyltin, allylbromides, allylchlorides, cyclic allylic halides, and allylboronic acid pinacol ester. Additionally, we have reviewed studies from 2001 to the present. The primary focus of this review is the overall progress in this field.