Lewis acid-promoted C–H Chalcogenation of Arenes and Heteroarenes

IF 2.5 3区化学 Q2 CHEMISTRY, ORGANIC

European Journal of Organic Chemistry Pub Date : 2024-10-16 DOI:10.1002/ejoc.202400894

Rahul Vishwakarma, Pragya Sharma, Chinmoy Kumar Hazra

引用次数: 0

Abstract

An efficient catalytic system employing TMS•OTf for the regioselective thiolation of electron-rich arenes with sulfonyl hydrazides has been developed. The reaction occurs in a solvent mixture of dichloroethane and trifluoroethanol under mild conditions, with the addition of water. This method furnishes a range of para-thio-substituted arenes and 3-sulfenyl-indoles in good to excellent yields, marking a significant advancement in organic synthesis.

查看原文本刊更多论文

路易斯酸促进的烯和杂环烯的 C-H Chalcogenation 反应

利用 TMS-OTf 开发出了一种高效催化系统，用于富电子烷与磺酰肼的区域选择性硫代反应。反应在二氯乙烷和三氟乙醇的混合溶剂中进行，条件温和，并加入水。这种方法可以提供一系列对硫代的炔类化合物和 3-亚磺酰基吲哚，收率从良好到极佳，是有机合成领域的一大进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Journal of Organic Chemistry 化学-有机化学

CiteScore

5.40

自引率

3.60%

发文量

752

审稿时长

1 months

期刊介绍： The European Journal of Organic Chemistry (2019 ISI Impact Factor 2.889) publishes Full Papers, Communications, and Minireviews from the entire spectrum of synthetic organic, bioorganic and physical-organic chemistry. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. The following journals have been merged to form two leading journals, the European Journal of Organic Chemistry and the European Journal of Inorganic Chemistry: Liebigs Annalen Bulletin des Sociétés Chimiques Belges Bulletin de la Société Chimique de France Gazzetta Chimica Italiana Recueil des Travaux Chimiques des Pays-Bas Anales de Química Chimika Chronika Revista Portuguesa de Química ACH—Models in Chemistry Polish Journal of Chemistry.