Versatility of 14-3-3 proteins and their roles in bone and joint-related diseases

IF 14.3 1区 医学 Q1 CELL & TISSUE ENGINEERING
Renpeng Zhou, Weirong Hu, Peter X. Ma, Chuan-ju Liu
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引用次数: 0

Abstract

Bone and joint-related diseases, including osteoarthritis (OA), rheumatoid arthritis (RA), and bone tumors, pose significant health challenges due to their debilitating effects on the musculoskeletal system. 14-3-3 proteins, a family of conserved regulatory molecules, play a critical role in the pathology of these diseases. This review discusses the intricate structure and multifunctionality of 14-3-3 proteins, their regulation of signaling pathways, and their interactions with other proteins. We underscore the significance of 14-3-3 proteins in the regulation of osteoblasts, osteoclasts, chondrocytes, and bone remodeling, all key factors in the maintenance and dysfunction of bone and joint systems. Specific focus is directed toward elucidating the contribution of 14-3-3 proteins in the pathology of OA, RA, and bone malignancies, where dysregulated 14-3-3-mediated signaling cascades have been implicated in the disease processes. This review illuminates how the perturbation of 14-3-3 protein interactions can lead to the pathological manifestations observed in these disorders, including joint destruction and osteolytic activity. We highlight cutting-edge research that positions 14-3-3 proteins as potential biomarkers for disease progression and as innovative therapeutic targets, offering new avenues for disease intervention and management.

14-3-3 蛋白的多样性及其在骨骼和关节相关疾病中的作用
骨与关节相关疾病,包括骨关节炎(OA)、类风湿性关节炎(RA)和骨肿瘤,由于对肌肉骨骼系统的破坏性影响,对健康构成了重大挑战。14-3-3 蛋白是一个保守的调控分子家族,在这些疾病的病理过程中起着至关重要的作用。本综述讨论了 14-3-3 蛋白的复杂结构和多功能性、它们对信号通路的调控以及它们与其他蛋白的相互作用。我们强调了 14-3-3 蛋白在调控成骨细胞、破骨细胞、软骨细胞和骨重塑中的重要性,这些都是骨与关节系统维护和功能障碍的关键因素。本研究特别关注阐明 14-3-3 蛋白在 OA、RA 和骨恶性肿瘤病理学中的作用,14-3-3 介导的信号级联失调与这些疾病的发生过程有关联。本综述阐明了 14-3-3 蛋白相互作用的紊乱如何导致这些疾病的病理表现,包括关节破坏和溶骨活动。我们重点介绍了将 14-3-3 蛋白质定位为疾病进展潜在生物标志物和创新治疗靶点的前沿研究,这些研究为疾病干预和管理提供了新途径。
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来源期刊
Bone Research
Bone Research CELL & TISSUE ENGINEERING-
CiteScore
20.00
自引率
4.70%
发文量
289
审稿时长
20 weeks
期刊介绍: Established in 2013, Bone Research is a newly-founded English-language periodical that centers on the basic and clinical facets of bone biology, pathophysiology, and regeneration. It is dedicated to championing key findings emerging from both basic investigations and clinical research concerning bone-related topics. The journal's objective is to globally disseminate research in bone-related physiology, pathology, diseases, and treatment, contributing to the advancement of knowledge in this field.
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