Brain Defense of Glycemia in Health and Diabetes

IF 6.2 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Diabetes Pub Date : 2024-10-14 DOI:10.2337/dbi24-0001

Zaman Mirzadeh, Chelsea Faber

引用次数: 0

Abstract

The brain coordinates the homeostatic defense of multiple metabolic variables, including blood glucose levels, in the context of ever-changing external and internal environments. The biologically defended level of glycemia (BDLG) is the net result of brain modulation of insulin-dependent mechanisms in cooperation with the islet, and insulin-independent mechanisms through direct innervation and neuroendocrine control of glucose effector tissues. In this article, we highlight evidence from animal and human studies to develop a framework for the brain’s core homeostatic functions—sensory/afferent, integration/processing, and motor/efferent—that contribute to the normal BDLG in health and its elevation in diabetes.

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健康和糖尿病患者大脑对血糖的防御能力

在瞬息万变的内外环境中，大脑协调着包括血糖水平在内的多种代谢变量的稳态防御。生物防御血糖水平（BDLG）是大脑与胰岛合作调节胰岛素依赖性机制以及通过直接神经支配和神经内分泌控制葡萄糖效应组织调节胰岛素非依赖性机制的净结果。在本文中，我们将重点介绍动物和人体研究的证据，从而为大脑的核心平衡功能--感觉/传感、整合/处理和运动/传感--建立一个框架，这些功能有助于健康状态下的正常 BDLG 以及糖尿病状态下的升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes 医学-内分泌学与代谢

CiteScore

12.50

自引率

2.60%

发文量

1968

审稿时长

1 months

期刊介绍： Diabetes is a scientific journal that publishes original research exploring the physiological and pathophysiological aspects of diabetes mellitus. We encourage submissions of manuscripts pertaining to laboratory, animal, or human research, covering a wide range of topics. Our primary focus is on investigative reports investigating various aspects such as the development and progression of diabetes, along with its associated complications. We also welcome studies delving into normal and pathological pancreatic islet function and intermediary metabolism, as well as exploring the mechanisms of drug and hormone action from a pharmacological perspective. Additionally, we encourage submissions that delve into the biochemical and molecular aspects of both normal and abnormal biological processes. However, it is important to note that we do not publish studies relating to diabetes education or the application of accepted therapeutic and diagnostic approaches to patients with diabetes mellitus. Our aim is to provide a platform for research that contributes to advancing our understanding of the underlying mechanisms and processes of diabetes.