Periodontitis impacts on thrombotic diseases: from clinical aspect to future therapeutic approaches.

IF 10.8 1区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

International Journal of Oral Science Pub Date : 2024-10-15 DOI:10.1038/s41368-024-00325-9

Jinting Ge,Xuanzhi Zhu,Chengxin Weng,Ding Yuan,Jichun Zhao,Lei Zhao,Tiehao Wang,Yafei Wu

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Abstract

Periodontitis is a chronic inflammatory disease initiated by biofilm microorganisms and mediated by host immune imbalance. Uncontrolled periodontal infections are the leading cause of tooth loss in adults. Thrombotic diseases can lead to partial or complete obstruction of blood flow in the circulatory system, manifesting as organ or tissue ischemia and necrosis in patients with arterial thrombosis, and local edema, pain and circulatory instability in patients with venous thrombosis, which may lead to mortality or fatality in severe case. Recent studies found that periodontitis might enhance thrombosis through bacterial transmission or systemic inflammation by affecting platelet-immune cell interactions, as well as the coagulation, and periodontal therapy could have a prophylactic effect on patients with thrombotic diseases. In this review, we summarized clinical findings on the association between periodontitis and thrombotic diseases and discussed several novel prothrombotic periodontitis-related agents, and presented a perspective to emphasize the necessity of oral health management for people at high risk of thrombosis.

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牙周炎对血栓性疾病的影响：从临床方面到未来的治疗方法。

牙周炎是一种由生物膜微生物引发并由宿主免疫失衡介导的慢性炎症性疾病。不受控制的牙周感染是成年人牙齿脱落的主要原因。血栓性疾病可导致循环系统血流部分或完全受阻，动脉血栓患者表现为器官或组织缺血坏死，静脉血栓患者表现为局部水肿、疼痛和循环不稳定，严重者可导致死亡。最新研究发现，牙周炎可能通过细菌传播或全身炎症影响血小板与免疫细胞的相互作用以及凝血功能，从而促进血栓形成，牙周治疗对血栓性疾病患者有预防作用。在这篇综述中，我们总结了牙周炎与血栓性疾病相关的临床研究结果，讨论了几种新型促血栓形成的牙周炎相关药物，并从一个角度强调了血栓高危人群口腔健康管理的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Oral Science DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

31.80

自引率

1.30%

发文量

审稿时长

>12 weeks

期刊介绍： The International Journal of Oral Science covers various aspects of oral science and interdisciplinary fields, encompassing basic, applied, and clinical research. Topics include, but are not limited to: Oral microbiology Oral and maxillofacial oncology Cariology Oral inflammation and infection Dental stem cells and regenerative medicine Craniofacial surgery Dental material Oral biomechanics Oral, dental, and maxillofacial genetic and developmental diseases Craniofacial bone research Craniofacial-related biomaterials Temporomandibular joint disorder and osteoarthritis The journal publishes peer-reviewed Articles presenting new research results and Review Articles offering concise summaries of specific areas in oral science.