Study of the Modifying Effect of 1-β-D-Arabinofuranosyl Cytosine on the Immune Status of Rats in the Long Period under the Exposure to Protons

IF 0.4 Q4 PHYSICS, PARTICLES & FIELDS

Physics of Particles and Nuclei Letters Pub Date : 2024-10-16 DOI:10.1134/S1547477124701632

E. V. Pronskikh, I. A. Kolesnikova, Yu. S. Severiukhin, D. M. Utina, K. N. Golikova, T. S. Khramko, M. Lalcovicova, A. G. Molokanov

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Abstract

The effect of the combined use of protons at a dose of 3 Gy and 1-β-D-arabinofuranosylcytosine (Ara-C) on the physiological parameters of immunocompetent organs on the 90th day was studied: the weight of the spleen, thymus, total leukocyte count, and leukogram were examined. A significant decrease in thymus mass was established under the combined action of protons and Ara-C; a trend was observed in all experimental groups towards a decrease in spleen weight compared to the reference group. A statistically significant increase in the number of leukocytes in the “Ara-C” group was revealed, without differences in their types distribution during visual differentiated counting. It is concluded that further research of combined use of the DNA replication and Ara-C repair inhibitor and various types of ionizing radiation may be a promising way for extending the therapeutic capabilities of oncological practice.

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1-β-D-阿拉伯呋喃糖基胞嘧啶对长期暴露于质子环境中的大鼠免疫状态的调节作用研究

研究了 3 Gy 剂量的质子和 1-β-D-arabinofuranosylcytosine (Ara-C) 联合使用对免疫器官在第 90 天的生理参数的影响：检测了脾脏、胸腺、白细胞总数和白细胞图谱的重量。在质子和 Ara-C 的共同作用下，胸腺质量明显下降；与参照组相比，所有实验组的脾脏重量都呈下降趋势。据统计，"Ara-C "组的白细胞数量明显增加，但在目视分化计数过程中，白细胞的类型分布没有差异。结论是，进一步研究 DNA 复制和 Ara-C 修复抑制剂与各种类型电离辐射的联合使用，可能是扩大肿瘤治疗能力的一种有前途的方法。

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来源期刊

Physics of Particles and Nuclei Letters PHYSICS, PARTICLES & FIELDS-

CiteScore

0.80

自引率

20.00%

发文量

108

期刊介绍： The journal Physics of Particles and Nuclei Letters, brief name Particles and Nuclei Letters, publishes the articles with results of the original theoretical, experimental, scientific-technical, methodological and applied research. Subject matter of articles covers: theoretical physics, elementary particle physics, relativistic nuclear physics, nuclear physics and related problems in other branches of physics, neutron physics, condensed matter physics, physics and engineering at low temperatures, physics and engineering of accelerators, physical experimental instruments and methods, physical computation experiments, applied research in these branches of physics and radiology, ecology and nuclear medicine.