The relationship between menstrual cycle characteristics, premenstrual syndrome prevalence and blood phenylalanine level in women with PKU

IF 1.8 4区医学 Q3 GENETICS & HEREDITY

Molecular Genetics and Metabolism Reports Pub Date : 2024-10-15 DOI:10.1016/j.ymgmr.2024.101154

Arzu Selamioğlu , Zelal Tandoğan , Mehmet Cihan Balcı , Meryem Karaca , Tuğba Kozanoğlu , Alihan Yesil , Gülden Gökçay

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引用次数: 0

Abstract

Phenylketonuria (PKU) results from a deficiency in phenylalanine hydroxylase, catalyzing the conversion of phenylalanine (Phe) to tyrosine. Premenstrual syndrome (PMS) consists of physical, behavioral, and emotional symptoms occurring during the last week of luteal phase. The aim of the study was to determine the incidence of PMS, and document menstrual cycle characteristics of PKU patients to reveal the relationship with blood Phe levels. The study was conducted on 74 patients with a mean age of 21.7 ± 5.4 years. The mean age at menarche was 12.7 ± 1.3 years and 82.4 % had regular menstrual cycles. The periods of most patients (47.2 %) lasted 4–5 days. Menstrual cycles of 21–28 days were reported by 73 %, less than 21 days by 8 %, and more than 28 days by 19 % of women. Menorrhagia and dysmenorrhea was observed in 6.7 % and 71.6 % respectively. Adherence to diet was lost in 7 patients during the menstrual period. No significant relationship was found between Phe levels and PMS symptoms (p > 0.05). According to PMSS subscales, 52.7 % of patients with PKU had depressive feelings, 16.2 % anxiety, 55.4 % fatigue, 52.7 % irritability, 28.3 % depressive thoughts, 39.1 % pain, 59.4 % changes in appetite, 28.3 % changes in sleeping habits and 43.2 % had swelling. The findings of the study revealed that PMS prevalence was 39.1 % among PKU women. Awareness about this syndrome, will improve the quality of life in women with PKU by evaluating and taking measures for PMS.

Synopsis

Evaluating menstrual cycle characteristics and premenstrual syndrome in phenylketonuria patients provides valuable insights for enhancing their overall health profile and personalizing treatment and management plans.

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患有 PKU 的妇女的月经周期特征、经前期综合征患病率与血液苯丙氨酸水平之间的关系

苯丙酮尿症（PKU）是由苯丙氨酸羟化酶缺乏引起的，该酶催化苯丙氨酸（Phe）向酪氨酸的转化。经前期综合征（PMS）包括黄体期最后一周出现的生理、行为和情绪症状。该研究旨在确定经前综合征的发病率，并记录北京大学患者的月经周期特征，以揭示其与血液中Phe水平的关系。研究对象为74名患者，平均年龄为（21.7 ± 5.4）岁。月经初潮的平均年龄为（12.7 ± 1.3）岁，82.4%的患者月经周期规律。大多数患者（47.2%）的月经周期为 4-5 天。月经周期为 21-28 天的妇女占 73%，少于 21 天的妇女占 8%，超过 28 天的妇女占 19%。月经过多和痛经的比例分别为 6.7% 和 71.6%。有 7 名患者在月经期间不注意饮食。Phe水平与经前综合征症状之间无明显关系（p > 0.05）。根据PMSS分量表，52.7%的北京大学患者有抑郁情绪，16.2%焦虑，55.4%疲劳，52.7%易怒，28.3%有抑郁想法，39.1%疼痛，59.4%食欲改变，28.3%睡眠习惯改变，43.2%有浮肿。研究结果显示，经前综合征在北京大学女性中的发病率为 39.1%。通过评估经前综合征并采取相应措施，对该综合征的认识将提高PKU女性患者的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Genetics and Metabolism Reports Biochemistry, Genetics and Molecular Biology-Endocrinology

CiteScore

4.00

自引率

5.30%

发文量

105

审稿时长

33 days

期刊介绍： Molecular Genetics and Metabolism Reports is an open access journal that publishes molecular and metabolic reports describing investigations that use the tools of biochemistry and molecular biology for studies of normal and diseased states. In addition to original research articles, sequence reports, brief communication reports and letters to the editor are considered.