N-Vinylation of lactams with calcium carbide water system

IF 1.8 4区化学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Mendeleev Communications Pub Date : 2024-09-01 DOI:10.1016/j.mencom.2024.09.034

Yulia V. Gyrdymova, Sofya M. Zarubina, Konstantin S. Rodygin

引用次数: 0

Abstract

Direct N-vinylation of lactams with calcium carbide water system was performed under super-basic conditions. The vinylation occurred exclusively at NH group leaving CO function intact to afford cyclic N-vinyl amides in yields up to 97%. The obtained products are prospective monomers for the preparation of synthetic peptides.

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内酰胺与碳化钙水体系的 N-乙烯基化反应

在超基本条件下，利用碳化钙水体系对内酰胺进行了直接 N-乙烯基化反应。乙烯基化完全发生在 NH 基团上，CO 功能保持不变，从而得到了环状 N-乙烯基酰胺，收率高达 97%。所获得的产品是制备合成肽的理想单体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mendeleev Communications 化学-化学综合

CiteScore

3.00

自引率

21.10%

发文量

226

审稿时长

4-8 weeks

期刊介绍： Mendeleev Communications is the journal of the Russian Academy of Sciences, launched jointly by the Academy of Sciences of the USSR and the Royal Society of Chemistry (United Kingdom) in 1991. Starting from 1st January 2007, Elsevier is the new publishing partner of Mendeleev Communications. Mendeleev Communications publishes short communications in chemistry. The journal primarily features papers from the Russian Federation and the other states of the former USSR. However, it also includes papers by authors from other parts of the world. Mendeleev Communications is not a translated journal, but instead is published directly in English. The International Editorial Board is composed of eminent scientists who provide advice on refereeing policy.