Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis

IF 2.9 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry Biochemistry Pub Date : 2024-10-14 DOI:10.1038/s41422-024-01040-0

Benoit Viollet, Bruno Guigas

引用次数: 0

Abstract

The capacity to effectively adapt metabolism to environmental demands is crucial for cell viability, proliferation, and function. Recent discoveries in Cell Research have highlighted the role of the lysosomal pool of AMPK in promoting glutaminolysis during glucose shortage through the activation of a PDZD8-GLS1 axis.

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为新陈代谢适应性提供燃料：溶酶体 AMPK 触发谷氨酰胺溶解

使新陈代谢有效适应环境需求的能力对细胞的活力、增殖和功能至关重要。最近《细胞研究》（Cell Research）杂志的研究发现，AMPK 的溶酶体池通过激活 PDZD8-GLS1 轴，在葡萄糖缺乏时促进谷氨酰胺分解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry Biochemistry 生物-生化与分子生物学

CiteScore

5.50

自引率

3.40%

发文量

336

审稿时长

1-2 weeks

期刊介绍： Biochemistry provides an international forum for publishing exceptional, rigorous, high-impact research across all of biological chemistry. This broad scope includes studies on the chemical, physical, mechanistic, and/or structural basis of biological or cell function, and encompasses the fields of chemical biology, synthetic biology, disease biology, cell biology, nucleic acid biology, neuroscience, structural biology, and biophysics. In addition to traditional Research Articles, Biochemistry also publishes Communications, Viewpoints, and Perspectives, as well as From the Bench articles that report new methods of particular interest to the biological chemistry community.