Inconsistent embryo selection across polygenic score methods

IF 21.4 1区心理学 Q1 MULTIDISCIPLINARY SCIENCES

Nature Human Behaviour Pub Date : 2024-10-14 DOI:10.1038/s41562-024-02019-y

Shinichi Namba, Masato Akiyama, Haruka Hamanoue, Kazuto Kato, Minae Kawashima, Itaru Kushima, Koichi Matsuda, Masahiro Nakatochi, Soichi Ogishima, Kyuto Sonehara, Ken Suzuki, Atsushi Takata, Gen Tamiya, Chizu Tanikawa, Kenichi Yamamoto, Natsuko Yamamoto, The BioBank Japan Project, Norio Ozaki, Yukinori Okada

引用次数: 0

Abstract

Private enterprises offer preimplantation genetic testing with polygenic scores to select embryos with ‘desirable’ potential. In silico simulations using biobank resources show that the selected embryo would rely substantially on the choice of polygenic score method and randomness in score construction, which raises ethical concerns.

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多基因评分法的胚胎选择不一致

私营企业提供植入前基因检测，通过多基因评分来选择具有 "理想 "潜力的胚胎。利用生物库资源进行的硅模拟显示，所选胚胎在很大程度上取决于多基因评分方法的选择和评分构建的随机性，这引起了伦理方面的关注。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Human Behaviour Psychology-Social Psychology

CiteScore

36.80

自引率

1.00%

发文量

227

期刊介绍： Nature Human Behaviour is a journal that focuses on publishing research of outstanding significance into any aspect of human behavior.The research can cover various areas such as psychological, biological, and social bases of human behavior.It also includes the study of origins, development, and disorders related to human behavior.The primary aim of the journal is to increase the visibility of research in the field and enhance its societal reach and impact.