Diagnostic accuracy of pleural fluid complement C1q for tuberculous pleural effusion in elderly patients

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2024-10-11 DOI:10.1016/j.cyto.2024.156778

Wen Zhao , Yan Niu , Jian-Xun Wen , Xi-Shan Cao , Yu-Ling Han , Xu-Hui Wen , Mei-Ying Wang , Ling Hai , Wen-Hui Gao , Li Yan , Wen-Qi Zheng , Zhi-De Hu

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引用次数: 0

Abstract

Background

Previous studies indicated that pleural fluid complement C1q was helpful for diagnosing tuberculous pleural effusion (TPE), but the participants in these studies were young. The diagnostic accuracy of C1q for TPE in elderly patients remains unknown. This study aimed to investigate the diagnostic accuracy of C1q for TPE in elderly patients.

Methods

We prospectively recruited patients with undiagnosed pleural effusion who visited the Affiliated Hospital of Inner Mongolia Medical University between September 2018 and July 2021. Their C1q in pleural fluid was detected, and the diagnostic accuracy of C1q was assessed by the receiver operating characteristic (ROC) curve analysis.

Results

The median ages of patients with TPE and non-TPE were 75 and 71 years, respectively. TPE patients had significantly higher C1q than non-TPE. The area under the ROC curve (AUC) of C1q was 0.67 (95 %CI: 0.51–0.82). At the threshold of 100 mg/L, C1q had a sensitivity of 0.44 (95 %CI: 0.19–0.69) and specificity of 0.79 (95 %CI: 0.71–0.86).

Conclusion

C1q in pleural fluid has low diagnostic accuracy for TPE in elderly patients.

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胸腔积液补体 C1q 对老年结核性胸腔积液的诊断准确性

背景以前的研究表明，胸腔积液补体C1q有助于诊断结核性胸腔积液（TPE），但这些研究的参与者都很年轻。C1q对老年患者TPE的诊断准确性仍不清楚。本研究旨在探讨C1q对老年患者TPE的诊断准确性。方法我们前瞻性地招募了2018年9月至2021年7月期间在内蒙古医科大学附属医院就诊的未确诊胸腔积液患者。结果TPE和非TPE患者的中位年龄分别为75岁和71岁。TPE患者的C1q明显高于非TPE患者。C1q的ROC曲线下面积（AUC）为0.67（95 %CI：0.51-0.82）。结论胸腔积液中的 C1q 对老年患者 TPE 的诊断准确性较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.