Omadacycline for the treatment of severe Legionella pneumophila pneumonia complicated with multiple organ dysfunction: a case report

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2024-10-10 DOI:10.1016/j.diagmicrobio.2024.116553

Jinfeng Lv , Chun Liu , Lan Fan , Ping Luo , Shao Liu , Cuifang Wu

{"title":"Omadacycline for the treatment of severe Legionella pneumophila pneumonia complicated with multiple organ dysfunction: a case report","authors":"Jinfeng Lv , Chun Liu , Lan Fan , Ping Luo , Shao Liu , Cuifang Wu","doi":"10.1016/j.diagmicrobio.2024.116553","DOIUrl":null,"url":null,"abstract":"<div><div>Omadacycline is a novel tetracycline antibiotic that has a strong <em>in vitro</em> antibacterial activity against atypical pathogen such as <em>Legionella</em>. It is approved for the treatment of adults with community-acquired bacterial pneumonia, including <em>Legionella</em> pneumonia. However, clinical data on the use of omadacycline in <em>Legionella</em> pneumonia is limited. In the present paper, we report a case of severe pneumonia induced by <em>Legionella pneumophila</em> (<em>L.pneumophila</em>) presenting with septic shock and multiple organ dysfunction including lung, liver and kidney. With omadacycline treaetment, inflammation indices of the patient markedly decreased, and the patient significantly improved with multiple organ dysfunction and was discharged from home. Due to its strong antibacterial activity against <em>L.pneumophila</em>, good safety profile and no dosage adjustment in patients with severe hepatic or renal impairment, omadacycline can be considered as an optimal treatment strategies for severe infections by such special pathogen. Whereas, more case reports are needed to support this conclusion.</div></div>","PeriodicalId":11329,"journal":{"name":"Diagnostic microbiology and infectious disease","volume":"110 4","pages":"Article 116553"},"PeriodicalIF":2.1000,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Diagnostic microbiology and infectious disease","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S073288932400378X","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Omadacycline is a novel tetracycline antibiotic that has a strong in vitro antibacterial activity against atypical pathogen such as Legionella. It is approved for the treatment of adults with community-acquired bacterial pneumonia, including Legionella pneumonia. However, clinical data on the use of omadacycline in Legionella pneumonia is limited. In the present paper, we report a case of severe pneumonia induced by Legionella pneumophila (L.pneumophila) presenting with septic shock and multiple organ dysfunction including lung, liver and kidney. With omadacycline treaetment, inflammation indices of the patient markedly decreased, and the patient significantly improved with multiple organ dysfunction and was discharged from home. Due to its strong antibacterial activity against L.pneumophila, good safety profile and no dosage adjustment in patients with severe hepatic or renal impairment, omadacycline can be considered as an optimal treatment strategies for severe infections by such special pathogen. Whereas, more case reports are needed to support this conclusion.

查看原文本刊更多论文

奥马他环素治疗严重嗜肺军团菌肺炎并发多器官功能障碍：病例报告

奥马他环素是一种新型四环素类抗生素，对军团菌等非典型病原体具有很强的体外抗菌活性。它被批准用于治疗成人社区获得性细菌性肺炎，包括军团菌肺炎。然而，有关奥马他环素用于军团菌肺炎的临床数据十分有限。本文报告了一例由嗜肺军团菌（L.pneumophila）诱发的重症肺炎病例，患者出现脓毒性休克和肺、肝、肾等多器官功能障碍。经奥美拉唑治疗后，患者的炎症指标明显降低，多器官功能障碍明显改善，康复出院。由于奥美拉唑对嗜肺菌有很强的抗菌活性，安全性好，且对严重肝肾功能损害的患者无需调整剂量，因此可将奥美拉唑作为此类特殊病原体严重感染的最佳治疗策略。不过，还需要更多的病例报告来支持这一结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.