Visible light mediated decarboxylative difluoroalkylations of cyclic N-sulfonyl ketimines: Efficient synthesis of difluoroalkylated Cα-tetrasubstituted α-amino acid derivatives

Abstract

An efficient decarboxylative difluoroalkylation method of cyclic N-sulfonyl ketimines with difluoroalkyl carboxylates has been developed through visible light-mediated photoredox catalysis process. This protocol provides a straightforward route for the synthesis of difluoroalkylated C^α-tetrasubstituted α-amino acid derivatives in moderate to good yields with excellent functional group tolerance under mild and simple conditions.