High-fidelity propionaldehyde functionalized Poly(ethylene glycol): Synthesis and applications

Abstract

An economical and efficient approach for synthesizing high-fidelity PEG_n-Alds through a substitution and oxidation process has been developed, providing a new pathway for obtaining high-purity PEG_n-Alds, particularly addressing the issue of peroxidation and breakage of PEG main chains in the oxidation step. The synthesis of a series of high-fidelity PEG_n-Alds with different functional groups or topological structures further proves the versatility of this new method. Additionally, PEG_n-Alds also exhibit good biocompatibility, and potential ability to modify peptides and self-assembly to micelles, this lays a foundation for synthesizing high-quality drugs and developing novel therapeutics.