A review of Viticis Fructus: botany, historical records, phytochemistry, pharmacology, toxicity, quality control, pharmacokinetics and comprehensive applications

IF 5.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Arabian Journal of Chemistry Pub Date : 2024-10-02 DOI:10.1016/j.arabjc.2024.106008

Xue Meng , Yang Liu , Suyi Liu , Qianqian Zhang , Kunze Du , Omachi Daniel Ogaji , Lirong Wang , Xingyue Jin , Jin Li , Yanxu Chang

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Abstract

Background

Viticis Fructus (also known as Manjingzi) has been used in China for more than 2000 years. It is one of the most famous traditional Chinese medicines with the main effect of dispelling wind-heat. In Asian countries, it is used in the treatment of common cold with wind-heat syndrome, swollen gums, migraines, dizziness, etc.

The aim of the review

The paper emphasizes on the botany, historical records, phytochemistry, pharmacology, toxicity, quality control, pharmacokinetics and comprehensive applications of Viticis Fructus to furnish with a scientific theoretical reference for its exploration and applications.

Materials and methods

Correlative data on Viticis Fructus were obtained from PubMed, ScienceDirect, Web of science, Embase, Scopus, Google Scholar, CNKI, WeiPu, Chinese ancient books and DuXiu academic search. The data collection ended in May 2024.

Results

The results showed 324 compounds, including terpenoids, flavonoids, lignans and others, which were isolated and identified from Viticis Fructus. In addition to treating headaches and eye pain, Viticis Fructus also had anti-inflammatory, antiplatelet activation, analgesia, antitumor and antihypertensive effects. In addition, this review summarized the botany, toxicity, counterfeit identification, pharmacokinetics and patent information of Viticis Fructus in detail. The shortcomings and feasible suggestions are put forward, which provide a basis for further research and utilization of Viticis Fructus.

Conclusion

Viticis Fructus has been used to remedy common cold with wind-heat syndrome, cephalalgia, ophthalmodynia, dizziness, etc. The pharmacological activities of the main components have been clarified and backed up the traditional applications. However, the botany, processing, pharmacological mechanism, quality control and toxicological studies of Viticis Fructus need to be further improved.

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枸橘综述：植物学、历史记录、植物化学、药理学、毒性、质量控制、药代动力学和综合应用

背景蔓荆子在中国已有 2000 多年的历史。它是最著名的传统中药之一，主要功效是祛风热。综述目的本文着重对蔓荆子的植物学、历史记载、植物化学、药理学、毒性、质量控制、药代动力学及综合应用进行了研究，为蔓荆子的开发和应用提供科学的理论参考。材料与方法有关蔓荆子的相关数据来自 PubMed、ScienceDirect、Web of science、Embase、Scopus、Google Scholar、CNKI、卫朴、中国古籍和独秀学术搜索。结果表明，从紫云英中分离并鉴定出 324 种化合物，包括萜类、黄酮类、木脂素等。除了治疗头痛和眼痛外，维蒂丝果实还具有抗炎、抗血小板激活、镇痛、抗肿瘤和降血压的作用。此外，本综述还详细总结了维药的植物学、毒性、假药识别、药代动力学和专利信息。结论蔓荆子用于治疗风热感冒、头痛、目赤、眩晕等症。其主要成分的药理活性已得到明确，并为传统应用提供了支持。然而，葡萄科植物的植物学、加工、药理机制、质量控制和毒理学研究还需要进一步完善。

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来源期刊

Arabian Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

10.80

自引率

3.30%

发文量

763

审稿时长

63 days

期刊介绍： The Arabian Journal of Chemistry is an English language, peer-reviewed scholarly publication in the area of chemistry. The Arabian Journal of Chemistry publishes original papers, reviews and short reports on, but not limited to: inorganic, physical, organic, analytical and biochemistry. The Arabian Journal of Chemistry is issued by the Arab Union of Chemists and is published by King Saud University together with the Saudi Chemical Society in collaboration with Elsevier and is edited by an international group of eminent researchers.