04INV Acquired muscle disorders - a paediatric perspective

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neuromuscular Disorders Pub Date : 2024-10-01 DOI:10.1016/j.nmd.2024.07.015

S. Ramdas

引用次数: 0

Abstract

Acquired muscle disorders comprise of a heterogenous group of treatable infectious or inflammatory disorders. Outside the benign self-limiting viral myositis, the most common acquired muscle disorders are Immune mediated myopathies (IIMs) which include juvenile dermatomyositis, juvenile polymyositis and immune-mediated necrotising myopathy. IIMs are rare in paediatric cohorts with an annual incidence of 1.6- 4 cases/million children compared to adult incidence of 0.2-2/100,000 person years, leading to diagnostic delay including misdiagnosis as genetic or para-infectious muscle disorders and consequently morbidity and mortality due to treatment delay. The talk will cover the pathophysiology mechanisms, clinical presentations, current and emerging treatment strategies in management of paediatric acquired muscle disorders focusing particularly on the nuances of the issues which are pertinent to children and young people compared to adults.

查看原文本刊更多论文

04INV 后天性肌肉疾病--儿科视角

获得性肌肉疾病包括一组可治疗的感染性或炎症性疾病。除良性自限性病毒性肌炎外，最常见的获得性肌肉疾病是免疫介导的肌病（IIMs），包括幼年皮肌炎、幼年多发性肌炎和免疫介导的坏死性肌病。免疫介导性肌病在儿科群体中十分罕见，年发病率为 1.6-4 例/百万儿童，而成人发病率为 0.2-2 例/十万人年，导致诊断延误，包括被误诊为遗传性或副感染性肌肉疾病，从而因治疗延误而发病和死亡。讲座将涵盖儿科获得性肌肉疾病的病理生理学机制、临床表现、当前和新出现的治疗策略，尤其关注与成人相比，儿童和青少年在这些问题上的细微差别。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Neuromuscular Disorders 医学-临床神经学

CiteScore

4.60

自引率

3.60%

发文量

543

审稿时长

53 days

期刊介绍： This international, multidisciplinary journal covers all aspects of neuromuscular disorders in childhood and adult life (including the muscular dystrophies, spinal muscular atrophies, hereditary neuropathies, congenital myopathies, myasthenias, myotonic syndromes, metabolic myopathies and inflammatory myopathies). The Editors welcome original articles from all areas of the field: • Clinical aspects, such as new clinical entities, case studies of interest, treatment, management and rehabilitation (including biomechanics, orthotic design and surgery). • Basic scientific studies of relevance to the clinical syndromes, including advances in the fields of molecular biology and genetics. • Studies of animal models relevant to the human diseases. The journal is aimed at a wide range of clinicians, pathologists, associated paramedical professionals and clinical and basic scientists with an interest in the study of neuromuscular disorders.