Prevalence and genotype distribution of high-risk Human Papillomavirus infection among Vietnamese women in Ho Chi Minh City, Viet Nam: A population-based cross-sectional study

IF 1.2 Q3 OBSTETRICS & GYNECOLOGY

Gynecologic Oncology Reports Pub Date : 2024-10-09 DOI:10.1016/j.gore.2024.101526

Ho Minh Nguyet , Phan Thanh Tam , Quach Kim Ung , To Gia Kien , Le Hong Phuoc

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Abstract

Introduction

Persistent infection with high-risk Human Papillomavirus (HR-HPV) genotypes are wellknown to increase the risk of cervical cancer significantly. This study aims to determine the prevalence and distribution of high-risk HR-HPV genotypes among women in Ho Chi Minh City (HCMC), Viet Nam.

Methods

A population-based cross-sectional study was conducted between June 2020 and September 2020 in all 24 districts of HCMC, Viet Nam. Socio-demographic and behavioral data were collected from 2478 women aged 25 to 65 who had sexual intercourse using a self-administered questionnaire. Vaginal swab specimens from all participants were collected to identify HR-HPV genotypes using Polymerase Chain Reaction (PCR) protocols.

Results

The prevalence of HR-HPV infection was 3.5 % (87 women, including 20 cases infected with multi-genotypes), 3.1 % in urban and 0.4 % in rural areas. The most detected HR-HPV genotypes among positive cases were 58 (25.3 %), 52 (21.8 %), 16 (21.8 %), 68 (10.3 %), 51 (10.34 %) and 18 (9.2 %). The prevalence of multi-type HR-HPV genotypes was 0.81 %, of which the most common co-infection genotypes were 52 and 58 (20.0 %), 16 and 56 (10.0 %), and 16 and 39 (10.0 %). The percentages of one-, two-, three-, and four-genotypes of HPV among positive cases were 77.0 %, 16.1 %, 4.6 % and 2.3 %, respectively.

Conclusions

Our findings explore a low prevalence of HR-HPV infection in Vietnamese women, of which genotypes 52 and 58 are more popular than 16 and 18. Continuously updated data on the genotype distribution of HPV are helpful for vaccine development and planning preventive activities to prevent HPV-related cancers.

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越南胡志明市越南妇女高危人类乳头瘤病毒感染的流行率和基因型分布：基于人口的横断面研究

导言：众所周知，持续感染高危人乳头瘤病毒（HR-HPV）基因型会显著增加罹患宫颈癌的风险。本研究旨在确定越南胡志明市（HCMC）妇女中高风险 HR-HPV 基因型的流行率和分布情况。方法：2020 年 6 月至 2020 年 9 月期间，在越南胡志明市的所有 24 个区开展了一项基于人群的横断面研究。通过自制问卷收集了 2478 名 25 至 65 岁有过性行为的女性的社会人口和行为数据。结果HR-HPV感染率为3.5%（87名妇女，包括20例多重基因型感染者），城市地区为3.1%，农村地区为0.4%。在阳性病例中，检测到的最多的 HR-HPV 基因型分别为 58（25.3%）、52（21.8%）、16（21.8%）、68（10.3%）、51（10.34%）和 18（9.2%）。多型 HR-HPV 基因型的流行率为 0.81%，其中最常见的合并感染基因型为 52 和 58（20.0%）、16 和 56（10.0%）以及 16 和 39（10.0%）。在阳性病例中，HPV 的一种、两种、三种和四种基因型所占比例分别为 77.0%、16.1%、4.6% 和 2.3%。不断更新的人乳头瘤病毒基因型分布数据有助于疫苗开发和预防人乳头瘤病毒相关癌症的预防活动规划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gynecologic Oncology Reports OBSTETRICS & GYNECOLOGY-

CiteScore

2.00

自引率

0.00%

发文量

183

审稿时长

41 days

期刊介绍： Gynecologic Oncology Reports is an online-only, open access journal devoted to the rapid publication of narrative review articles, survey articles, case reports, case series, letters to the editor regarding previously published manuscripts and other short communications in the field of gynecologic oncology. The journal will consider papers that concern tumors of the female reproductive tract, with originality, quality, and clarity the chief criteria of acceptance.