{"title":"Haematological problems in intensive care: recent advances and developments","authors":"Samantha Gaw, Christopher J Wright","doi":"10.1016/j.mpaic.2024.07.004","DOIUrl":null,"url":null,"abstract":"<div><div>There have been significant changes in the management of several haematological conditions over the last decade. This article focuses on three key areas – chimeric antigen receptor (CAR) T-cell therapy, haemophagocytic lymphohistiocytosis (HLH) and thrombotic thrombocytopenic purpura (TTP) – and the implications these areas have for clinicians working in intensive care medicine. There is particular focus on CAR T-cell therapy given its novel nature and implications for both critical care practice and resource utilization.</div></div>","PeriodicalId":45856,"journal":{"name":"Anaesthesia and Intensive Care Medicine","volume":"25 10","pages":"Pages 657-663"},"PeriodicalIF":0.2000,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Anaesthesia and Intensive Care Medicine","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1472029924001450","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ANESTHESIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
There have been significant changes in the management of several haematological conditions over the last decade. This article focuses on three key areas – chimeric antigen receptor (CAR) T-cell therapy, haemophagocytic lymphohistiocytosis (HLH) and thrombotic thrombocytopenic purpura (TTP) – and the implications these areas have for clinicians working in intensive care medicine. There is particular focus on CAR T-cell therapy given its novel nature and implications for both critical care practice and resource utilization.
过去十年中,一些血液病的治疗方法发生了重大变化。本文将重点关注三个关键领域--嵌合抗原受体(CAR)T 细胞疗法、嗜血细胞淋巴组织细胞增多症(HLH)和血栓性血小板减少性紫癜(TTP)--以及这些领域对重症医学临床医生的影响。鉴于 CAR T 细胞疗法的新颖性及其对重症监护实践和资源利用的影响,该研究特别关注 CAR T 细胞疗法。
期刊介绍:
Anaesthesia and Intensive Care Medicine, an invaluable source of up-to-date information, with the curriculum of both the Primary and Final FRCA examinations covered over a three-year cycle. Published monthly this ever-updating text book will be an invaluable source for both trainee and experienced anaesthetists. The enthusiastic editorial board, under the guidance of two eminent and experienced series editors, ensures Anaesthesia and Intensive Care Medicine covers all the key topics in a comprehensive and authoritative manner. Articles now include learning objectives and eash issue features MCQs, facilitating self-directed learning and enabling readers at all levels to test their knowledge. Each issue is divided between basic scientific and clinical sections. The basic science articles include anatomy, physiology, pharmacology, physics and clinical measurement, while the clinical sections cover anaesthetic agents and techniques, assessment and perioperative management. Further sections cover audit, trials, statistics, ethical and legal medicine, and the management of acute and chronic pain.