Nanodots functionalized with chitooligosaccharides for blocking chitoporins

IF 5.4 2区医学 Q1 BIOPHYSICS

Colloids and Surfaces B: Biointerfaces Pub Date : 2024-10-02 DOI:10.1016/j.colsurfb.2024.114284

Thao P. Doan-Nguyen , Anuwat Aunkham , Patitta Preedanorawut , Thanida Chanpong , Albert Schulte , Daniel Crespy , Wipa Suginta

引用次数: 0

Abstract

We report the synthesis of functionalized nanodots as potential powerful blockers of solute transport through a chitoporin. Ultrasmall silica nanocapsules with a diameter of ∼ 6 nm were coated with chitooligosaccharides to be used as a “lid” binding to the opening of the chitoporin VhChiP of Vibrio campbellii. Efficient blocking is attributed to the adequate size of the nanodots and their functionalization with oligochitosan, which has strong affinity towards the Vibrio chitoporin. This strategy paves the way towards the development of nanomaterials for blocking other porins.

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用壳寡糖功能化的纳米点阻断壳聚糖

我们报告了功能化纳米点的合成情况，这些纳米点是通过壳多糖进行溶质运输的潜在强力阻断剂。直径为 6 纳米的超小型二氧化硅纳米胶囊上涂有壳寡糖，可作为 "盖子 "与坎贝尔弧菌的壳聚糖 VhChiP 的开口结合。之所以能有效阻断，是因为纳米点的尺寸足够大，而且与低聚壳聚糖功能化，后者对弧菌壳多糖有很强的亲和力。这一策略为开发用于阻断其他孔蛋白的纳米材料铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Colloids and Surfaces B: Biointerfaces 生物-材料科学：生物材料

CiteScore

11.10

自引率

3.40%

发文量

730

审稿时长

42 days

期刊介绍： Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields. Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication. The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.