Evaluation of the Chetomin effect on histopathological features in a murine acute spinal cord injury model

Q1 Medicine

World Neurosurgery: X Pub Date : 2024-09-26 DOI:10.1016/j.wnsx.2024.100414

Carlos César Bravo-Reyna , Vladimir Miranda-Galván , Gervith Reyes-Soto , R. Vicuña , Jorge Alanis-Mendizabal , Manuel Escobar-Valderrama , David Arango , Claudia J. Bautista , Victoria Ramírez , Gonzalo Torres-Villalobos

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Abstract

Background

Several research studies have been focused on improving the treatment and prognosis of acute spinal cord injury, as part of this initiative we investigated the use of Chetomin to reduce the inflammatory response in this pathology.

Methods

An experimental, prospective, cross-sectional study was performed using 42 Wistar rats where we analyzed the effect of Chetomin compared to methylprednisolone administered 1 and 8 h after the spinal cord injury in a murine model.

Results

Chetomin administration 8h post-injury decreased IL-6 and VEGF expression; and, and its administration 1h post-injury decreased NF-kB expression.

Conclusions

Chetomin has anti-inflammatory effects in acute spinal cord injury, whether these effects are observable with other proinflammatory markers should be investigated.

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评估 Chetomin 对小鼠急性脊髓损伤模型组织病理学特征的影响

方法我们使用 42 只 Wistar 大鼠进行了一项实验性、前瞻性、横断面研究，在小鼠模型中分析了脊髓损伤后 1 小时和 8 小时服用 Chetomin 与甲基强的松龙相比的效果。结论 Chetomin 对急性脊髓损伤有抗炎作用，但这些作用是否可通过其他促炎标记物观察到，还有待进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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