A Study of the Survival of Tumor A549 Cells upon Proton Beam Irradiation in Flash and Standard Modes

IF 4.033 Q4 Biochemistry, Genetics and Molecular Biology

Biophysics Pub Date : 2024-09-27 DOI:10.1134/S0006350924700349

A. V. Rzyanina, G. V. Mytsin, A. V. Agapov, E. A. Gritskova, S. S. Uglova, V. N. Gaevsky, K. N. Shipulin, I. Khassenova

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Abstract

Flash irradiation is an innovative method of therapy, which ensures that the therapeutic dose is brought to the pathological focus in times of the order of several tens of milliseconds. In this mode of irradiation, the degree of damage to normal tissues surrounding the tumor that fall under the influence of radiation decreases; at the same time, the effect on cancer cells remains at almost the same level, which improves the prospect of local control of the tumor with a lower frequency of side effects. The exact radiobiological mechanisms underlying the flash effect are not completely clear. This paper presents the results of work on the formation of a high-intensity proton beam with an energy of 660 MeV from the phasotron accelerator of the Joint Institute for Nuclear Research (Dubna), designed to conduct radiobiological studies of flash irradiation therapy on cell cultures and small laboratory animals (mice and rats). The survival rate of A549 cells under proton beam irradiation in flash and standard modes was compared. A difference was found in the change in the survival rate of A549 cells irradiated in flash and standard modes. The magnitude of the flash effect was represented by the dose change factor.

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质子束以闪光和标准模式照射 A549 肿瘤细胞时的存活率研究

闪光照射是一种创新的治疗方法，它能确保在几十毫秒的时间内将治疗剂量送达病灶。在这种辐照模式下，肿瘤周围正常组织受辐射影响的损伤程度会降低；与此同时，对癌细胞的影响几乎保持在同一水平，从而改善了肿瘤局部控制的前景，并降低了副作用的发生频率。闪光效应的确切放射生物学机制尚不完全清楚。本文介绍了从联合核研究所（杜布纳）的相控加速器中产生的能量为 660 兆电子伏特的高强度质子束的工作成果，旨在对细胞培养物和小型实验动物（小鼠和大鼠）进行闪光照射疗法的放射生物学研究。比较了质子束在闪光和标准模式下照射 A549 细胞的存活率。结果发现，在闪光模式和标准模式下照射的 A549 细胞存活率的变化存在差异。闪光效应的大小用剂量变化系数表示。

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来源期刊

Biophysics Biochemistry, Genetics and Molecular Biology-Biophysics

CiteScore

1.20

自引率

0.00%

发文量

期刊介绍： Biophysics is a multidisciplinary international peer reviewed journal that covers a wide scope of problems related to the main physical mechanisms of processes taking place at different organization levels in biosystems. It includes structure and dynamics of macromolecules, cells and tissues; the influence of environment; energy transformation and transfer; thermodynamics; biological motility; population dynamics and cell differentiation modeling; biomechanics and tissue rheology; nonlinear phenomena, mathematical and cybernetics modeling of complex systems; and computational biology. The journal publishes short communications devoted and review articles.