Advancements and regulations of biomanufacturing cell-based cartilage repair therapies.

IF 14.3 1区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Trends in biotechnology Pub Date : 2024-10-10 DOI:10.1016/j.tibtech.2024.09.016

Jia Qian Tor, Quang Bach Le, Hariharan Ezhilarasu, Weng Wan Chan, Deepak Choudhury

引用次数: 0

Abstract

Cell-based therapies for cartilage repair, including autologous chondrocyte implantation and allogeneic stem cell treatments, show great promise but face challenges due to high costs and regulatory hurdles. This review summarizes available and investigational products, focusing on allogeneic therapies and the impact of diverse regulatory landscapes on their clinical translation.

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以细胞为基础的软骨修复疗法的生物制造进展和法规。

以细胞为基础的软骨修复疗法，包括自体软骨细胞植入和异体干细胞治疗，显示出巨大的前景，但由于高成本和监管障碍，面临着挑战。本综述总结了现有和研究中的产品，重点关注异体疗法以及不同监管环境对其临床转化的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Trends in biotechnology 工程技术-生物工程与应用微生物

CiteScore

28.60

自引率

1.20%

发文量

198

审稿时长

1 months

期刊介绍： Trends in Biotechnology publishes reviews and perspectives on the applied biological sciences, focusing on useful science applied to, derived from, or inspired by living systems. The major themes that TIBTECH is interested in include: Bioprocessing (biochemical engineering, applied enzymology, industrial biotechnology, biofuels, metabolic engineering) Omics (genome editing, single-cell technologies, bioinformatics, synthetic biology) Materials and devices (bionanotechnology, biomaterials, diagnostics/imaging/detection, soft robotics, biosensors/bioelectronics) Therapeutics (biofabrication, stem cells, tissue engineering and regenerative medicine, antibodies and other protein drugs, drug delivery) Agroenvironment (environmental engineering, bioremediation, genetically modified crops, sustainable development).