Association Between Migraine and Open Angle Glaucoma: A 12-Year Nationwide Retrospective Korean Cohort Study.

IF 2 4区 医学 Q2 OPHTHALMOLOGY
Journal of Glaucoma Pub Date : 2025-01-01 Epub Date: 2024-10-11 DOI:10.1097/IJG.0000000000002507
Hyung Jun Kim, Jun-Soo Ro, Seung Hoon Lee, Jong Youn Moon, Si Hyung Lee
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引用次数: 0

Abstract

Prcis: Patients with migraine showed a significantly increased risk of developing open angle glaucoma (OAG) in the Korean population, without significant differences according to the presence of aura. Our results suggest the presence of migraine as a possible risk factor for OAG.

Purpose: Previous studies have reported that migraine headaches may be one of the possible risk factors for open angle glaucoma (OAG); however, a consensus has not been reached regarding the association between OAG and migraine. In this study, we examined the risk of developing OAG in migraine patients using a 12-year nationwide cohort.

Materials and methods: In this study, data from the Korean National Health Insurance Service-National Sample Cohort database from 2002 to 2015 was used to perform a retrospective cohort study. The study included 1,103,302 subjects, out of which 41,148 were diagnosed with migraine during 2003-2008 and were categorized as the migraine group, while 205,741 patients were selected as controls through propensity score matching at a 1:5 ratio. Subjects with migraine or OAG was ascertained based on the KCD code. Multivariate Cox regression analysis was used to evaluate the hazard rate of OAG onset in the migraine group, and subgroup analysis was performed to identify any differences based on sex and age.

Results: Multivariate Cox regression analysis showed that the incidence of OAG was significantly greater among patients with migraine than among patients in the comparison group [hazard ratio (HR): 1.238; 95% CI: 1.160-1.132, P < 0.001]. Moreover, the risk of developing OAG compared with subjects without migraine did not differ according to the presence of an aura (migraine with aura: HR: 1.235; 95% CI: 1.137-1.342, P < 0.001; migraine without aura: HR: 1.248; 95% CI: 1.143-1.363, P < 0.001). In subgroup analyses, the patients with migraine under 40-year-old were found to have a greater hazard rate (HR: 1.576, 95% CI: 1.268-1.957) of developing OAG in contrast with patients with migraine and over 40-year-old (HR: 1.167, 95% CI: 1.089-1.250) when compared with the corresponding nonmigraine patients.

Conclusion: This study showed that migraine is a significant risk factor for OAG onset in the Korean population, and the presence of aura did not affect the HR of OAG development.

偏头痛与开角型青光眼之间的关系:一项为期十二年的韩国全国性回顾性队列研究。
目的:先前的研究报告称,偏头痛可能是导致开角型青光眼(OAG)的风险因素之一;然而,关于 OAG 与偏头痛之间的关联尚未达成共识。在这项研究中,我们利用一项为期 12 年的全国性队列研究,对偏头痛患者罹患开角型青光眼的风险进行了调查:本研究使用了韩国国民健康保险服务-全国抽样队列数据库中 2002 年至 2015 年的数据,进行了一项回顾性队列研究。研究纳入了 1,103,302 名受试者,其中 41,148 人在 2003-2008 年期间被诊断为偏头痛,被归为偏头痛组,205,741 名患者通过倾向得分匹配以 1:5 的比例被选作对照组。根据 KCD 编码确定受试者是否患有偏头痛或 OAG。采用多变量 Cox 回归分析评估偏头痛组中 OAG 发病的危险率,并进行亚组分析以确定基于性别和年龄的任何差异:多变量 Cox 回归分析显示,偏头痛患者的 OAG 发病率明显高于对比组患者(危险比 [HR] 1.238;95% 置信区间 [CI] 1.160-1.132,P < 0.001)。此外,与无偏头痛的患者相比,有先兆的患者发生OAG的风险没有差异(有先兆的偏头痛:HR 1.235;95% CI 1.137-1.342,P <0.001;无先兆的偏头痛:HR 1.248;95% CI 1.143-1.363,P <0.001)。在亚组分析中发现,与相应的非偏头痛患者相比,40岁以下的偏头痛患者发生OAG的危险率(HR 1.576,95%CI:1.268-1.957)高于40岁以上的偏头痛患者(HR 1.167,95%CI:1.089-1.250):本研究表明,偏头痛是韩国人群中 OAG 发病的重要危险因素,而先兆的存在并不影响 OAG 发病的危险率:在韩国人群中,偏头痛患者罹患 OAG 的风险明显增加,但先兆的存在与否并无明显差异。我们的研究结果表明,偏头痛可能是导致 OAG 的一个风险因素。
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来源期刊
Journal of Glaucoma
Journal of Glaucoma 医学-眼科学
CiteScore
4.20
自引率
10.00%
发文量
330
审稿时长
4-8 weeks
期刊介绍: The Journal of Glaucoma is a peer reviewed journal addressing the spectrum of issues affecting definition, diagnosis, and management of glaucoma and providing a forum for lively and stimulating discussion of clinical, scientific, and socioeconomic factors affecting care of glaucoma patients.
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