The role of myocardial regeneration, cardiomyocyte apoptosis in acute myocardial infarction: A review of current research trends and challenges.

IF 2.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Journal of cardiology Pub Date : 2024-10-09 DOI:10.1016/j.jjcc.2024.09.012

Dan Yan, Shifang Zhan, Chenyu Guo, Jiawen Han, Lin Zhan, Qianyi Zhou, Dan Bing, Xiaoyan Wang

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引用次数: 0

Abstract

Purpose: This paper aims to review the research progress in repairing injury caused by acute myocardial infarction, focusing on myocardial regeneration, cardiomyocyte apoptosis, and fibrosis. The goal is to investigate the current research trends and challenges in the field of myocardial injury repair.

Methods: The review delves into the latest research on myocardial regeneration, cardiomyocyte apoptosis, and fibrosis following acute myocardial infarction. It highlights stem cell transplantation and gene therapy as key areas of current research focus, while emphasizing the significance of cardiomyocyte apoptosis and fibrosis in the myocardial injury repair process. Additionally, the review addresses the challenges and unresolved issues that require further investigation in the field of myocardial injury repair.

Summary: Acute myocardial infarction is a prevalent cardiovascular condition that results in myocardial damage necessitating repair. Myocardial regeneration plays a crucial role in repairing myocardial injury, with current research focusing on stem cell transplantation and gene therapy. Cardiomyocyte apoptosis and fibrosis are key factors in the repair process, significantly impacting the restoration of myocardial structure and function. Nonetheless, there remain numerous challenges and unresolved issues that warrant further investigation in the realm of myocardial injury repair.

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心肌再生、心肌细胞凋亡在急性心肌梗死中的作用：当前研究趋势与挑战综述。

目的：本文旨在回顾急性心肌梗死损伤修复的研究进展，重点关注心肌再生、心肌细胞凋亡和纤维化。目的是探讨当前心肌损伤修复领域的研究趋势和挑战：本综述深入探讨了有关急性心肌梗死后心肌再生、心肌细胞凋亡和纤维化的最新研究。它强调干细胞移植和基因治疗是当前研究的重点领域，同时强调心肌细胞凋亡和纤维化在心肌损伤修复过程中的重要意义。此外，综述还探讨了心肌损伤修复领域需要进一步研究的挑战和悬而未决的问题。摘要：急性心肌梗死是一种常见的心血管疾病，它导致心肌损伤，必须进行修复。心肌再生在修复心肌损伤中起着至关重要的作用，目前的研究重点是干细胞移植和基因治疗。心肌细胞凋亡和纤维化是修复过程中的关键因素，对心肌结构和功能的恢复有重大影响。尽管如此，在心肌损伤修复领域仍有许多挑战和悬而未决的问题需要进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

4.90

自引率

8.00%

发文量

202

审稿时长

29 days

期刊介绍： The official journal of the Japanese College of Cardiology is an international, English language, peer-reviewed journal publishing the latest findings in cardiovascular medicine. Journal of Cardiology (JC) aims to publish the highest-quality material covering original basic and clinical research on all aspects of cardiovascular disease. Topics covered include ischemic heart disease, cardiomyopathy, valvular heart disease, vascular disease, hypertension, arrhythmia, congenital heart disease, pharmacological and non-pharmacological treatment, new diagnostic techniques, and cardiovascular imaging. JC also publishes a selection of review articles, clinical trials, short communications, and important messages and letters to the editor.