Differentiation of osteoblastic metastases and bone islands on dual-energy computed tomography in patients with untreated lung cancer

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2024-10-01 DOI:10.1016/j.ejrad.2024.111770

Jie Li , Linfeng Cai , Nan Jiang , Jianfang Liu

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引用次数: 0

Abstract

Objective

To evaluate the diagnostic efficacy of quantitative dual-energy computed tomography (CT) parameters for distinguishing osteoblastic metastases (OBMs) from bone islands (BIs) in untreated lung cancer.

Material and Methods

Dual-energy CT images of 24 patients with OBMs and 56 patients with BIs obtained between January 2019 and December 2021 were retrospectively analyzed. The CT_70keV value, calcium_(water) density [Dcalcium_(water)], and water_(calcium) density [Dwater_(calcium)] were analyzed. Diagnostic performance was assessed by measuring the area under the curve (AUC), and specificity, sensitivity, and accuracy were determined.

Results

A total of 70 OBMs and 67 BIs were included. The AUC values of CT_70keV, Dcalcium_(water), and Dwater_(calcium) showed no significant differences (0.950 vs. 0.947 vs. 0.929, respectively; P > 0.05). The optimal CT_70keV cutoff value was 885.1 HU, with specificity, sensitivity, and accuracy of 81.4 %, 92.5 %, and 86.9 %, respectively. When using Dcalcium(water) < 254.9 mg/cm³ and Dwater(calcium) < 1250.6 mg/cm³, respectively, 119 of 137 lesions showed consistent diagnostic results (true or false). Sub-analysis of these 119 lesions showed specificity of 92.1 %, which was higher than that of CT_70keV (P = 0.021). The AUC, sensitivity, and accuracy were 0.974, 92.9 %, and 92.4 %, respectively, which were not significantly different from those of CT_70keV (P = 0.230, 0.906, and 0.220, respectively). Among the 18 lesions showing inconsistent diagnoses, Dcalcium_(water) diagnosed 11 lesions correctly, and Dwater_(calcium) diagnosed the remaining seven lesions correctly.

Conclusion

The combination of Dcalcium_(water) and Dwater_(calcium) demonstrated a promising role in the differentiation of OBMs from BIs in lung cancer patients.

查看原文本刊更多论文

未经治疗的肺癌患者在双能计算机断层扫描上的成骨细胞转移灶和骨岛的鉴别。

目的评估定量双能计算机断层扫描（CT）参数对区分未经治疗的肺癌骨细胞转移瘤（OBM）和骨岛（BI）的诊断效果：回顾性分析了2019年1月至2021年12月期间获得的24例OBMs患者和56例BIs患者的双能CT图像。分析了 CT70keV 值、钙（水）密度[Dcalcium（water）]和水（钙）密度[Dwater（钙）]。通过测量曲线下面积（AUC）评估诊断性能，并确定特异性、敏感性和准确性：结果：共纳入了 70 例 OBM 和 67 例 BI。CT70keV、Dcalcium（水）和 Dwater（钙）的 AUC 值无显著差异（分别为 0.950 vs. 0.947 vs. 0.929；P > 0.05）。CT70keV 的最佳临界值为 885.1 HU，其特异性、敏感性和准确性分别为 81.4%、92.5% 和 86.9%。当分别使用 Dcalcium(water) 3 和 Dwater(calcium) 3 时，137 个病灶中有 119 个显示出一致的诊断结果（真或假）。对这 119 个病灶的子分析表明，特异性为 92.1%，高于 CT70keV（P = 0.021）。AUC、灵敏度和准确度分别为 0.974 %、92.9 % 和 92.4 %，与 CT70keV 的差异不大（P = 0.230、0.906 和 0.220）。在诊断不一致的 18 个病灶中，Dcalcium（水）正确诊断了 11 个病灶，Dwater（钙）正确诊断了其余 7 个病灶：D钙（水）和D水（钙）的组合在肺癌患者OBM和BI的鉴别中表现出了良好的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.