Authors’ reply to comments on “Improved photostability, solubility, hygroscopic stability and antimicrobial activity of fleroxacin by synthesis of fleroxacin-D-tartaric acid pharmaceutical salt”

IF 4.4 2区医学 Q1 PHARMACOLOGY & PHARMACY

European Journal of Pharmaceutics and Biopharmaceutics Pub Date : 2024-10-10 DOI:10.1016/j.ejpb.2024.114519

Lixin Liu, Yuning Wang, Jiuyi Sun, Yunan Zhang, Xiangyu Zhang, Lili Wu, Yingli Liu, Xuan Zhang, Yidi Xia, Qiumei Zhang, Ning Gao

引用次数: 0

Abstract

This article responds to Dr. Shayanfar’s comment “Improvement of photostability, solubility, hygroscopic stability and antimicrobial activity of fleroxacin by synthesizing fleroxacin-D-tartaric acid pharmaceutical salt”. We rationalized and explained the solubility study portion of the published novel pharmaceutical salt (fleroxacin-D-tartaric acid, FL-D-TT). This confirms that the results of the solubility studies of fleroxacin (FL) and its pharmaceutical salt (FL-D-TT) in our published articles are true and accurate and consistent with the theoretical analysis.

查看原文本刊更多论文

作者对 "通过合成氟罗沙星-D-酒石酸药用盐改善氟罗沙星的光稳定性、溶解性、吸湿稳定性和抗菌活性 "的评论意见的回复。

s:本文是对 Shayanfar 博士的评论 "通过合成氟罗沙星-D-酒石酸药用盐改善氟罗沙星的光稳定性、溶解性、吸湿稳定性和抗菌活性 "的回应。我们对已发表的新型药用盐（氟罗沙星-D-酒石酸，FL-D-TT）的溶解度研究部分进行了合理的解释和说明。这证实了我们发表的文章中关于氟罗沙星（FL）及其药用盐（FL-D-TT）的溶解度研究结果是真实准确的，与理论分析是一致的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

European Journal of Pharmaceutics and Biopharmaceutics 医学-药学

CiteScore

8.80

自引率

4.10%

发文量

211

审稿时长

36 days

期刊介绍： The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for the publication of novel, innovative and hypothesis-driven research from the areas of Pharmaceutics and Biopharmaceutics. Topics covered include for example: Design and development of drug delivery systems for pharmaceuticals and biopharmaceuticals (small molecules, proteins, nucleic acids) Aspects of manufacturing process design Biomedical aspects of drug product design Strategies and formulations for controlled drug transport across biological barriers Physicochemical aspects of drug product development Novel excipients for drug product design Drug delivery and controlled release systems for systemic and local applications Nanomaterials for therapeutic and diagnostic purposes Advanced therapy medicinal products Medical devices supporting a distinct pharmacological effect.